UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant ☒   Filed by a party other than the Registrant ☐

Check the appropriate box:

Landos Biopharma, Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check all boxes that apply):

PRELIMINARY PROXY STATEMENT—SUBJECT TO COMPLETION, DATED APRIL 15, 2024

Landos Biopharma, Inc.

P.O. Box 11239

Blacksburg, Virginia 24062

Dear Landos Biopharma, Inc. Stockholder:

You are cordially invited to attend a virtual special meeting (including any adjournments or postponements thereof, the “Special Meeting”) of stockholders of Landos Biopharma, Inc. (“Landos”) to be held virtually on     , 2024, at      Eastern Time via live audio webcast on the Internet at www.virtualshareholdermeeting.com/LABP2024SM. The accompanying proxy statement is dated     , 2024 and, together with the enclosed form of proxy card, is first being mailed on or about     , 2024.

At the Special Meeting, you will be asked to consider and vote on (i) a proposal to adopt the Agreement and Plan of Merger, dated March 24, 2024 (such agreement, as it may be amended, modified or supplemented from time to time, the “Merger Agreement”), by and among Landos, Bespin Subsidiary, LLC, a Delaware limited liability company and a wholly owned subsidiary of AbbVie (“Parent”), and Bespin Merger Sub, Inc., a Delaware corporation and a wholly owned subsidiary of Parent (“Merger Sub”), and AbbVie Inc., a Delaware corporation (“AbbVie” or “Guarantor”), solely for the limited purposes set forth therein, and (ii) a proposal to approve the adjournment of the Special Meeting to a later date or dates, if necessary or appropriate, including to solicit additional proxies to approve the proposal to adopt the Merger Agreement if there are insufficient votes to adopt the Merger Agreement at the time of the Special Meeting (the “Adjournment Proposal”). Upon the terms and subject to the conditions of the Merger Agreement, Merger Sub will merge with and into Landos, with Landos continuing as the surviving corporation and a wholly owned subsidiary of Parent (the “Merger”).

If the Merger is completed, you will be entitled to receive (i) $20.42 in cash, without interest thereon and subject to any withholding of taxes, for each share of Landos common stock (“common stock”) that you own (unless you have properly exercised your appraisal rights), which represents a premium of approximately 161% to the closing price of $7.83 of Landos’ common stock on March 22, 2024, the last full trading day prior to the announcement of the Merger and (ii) one (1) contractual contingent value right for each share of common stock that you own (unless you have properly exercised your appraisal rights), representing the right to receive a contingent payment in cash, without interest thereon and subject to any withholding of taxes, upon the achievement of the milestone requirements set forth in the Contingent Value Rights Agreement (the “CVR Agreement”) between Parent, Broadridge Corporate Issuer Solutions, LLC (the “Rights Agent”) and AbbVie, for the limited purposes set forth therein, in substantially the form attached to the Merger Agreement.

Landos’ Board of Directors (the “Board of Directors”), after considering the factors more fully described in the enclosed proxy statement, has unanimously (a) determined that the consummation of the Merger, the other transactions contemplated by the Merger Agreement, the Merger Agreement, the CVR Agreement and the Voting Agreement (the “Transactions”), are advisable and fair to, and in the best interests of, Landos and its stockholders; (b) authorized and approved the execution, delivery, and performance of the Merger Agreement, the CVR Agreement and the Voting Agreement by Landos and approved the Merger; (c) recommended the adoption of the Merger Agreement by Landos’ stockholders and (d) directed that the Merger Agreement be submitted for consideration by Landos’ stockholders at the Special Meeting. The Board of Directors unanimously recommends, on behalf of Landos, that you vote (1) “FOR” the adoption of the Merger Agreement and (2) “FOR” the Adjournment Proposal.

Landos record stockholders or beneficial owners who do not vote in favor of the proposal to adopt the Merger Agreement will have the right to seek appraisal of the “fair value” of their shares of our common stock (exclusive of any elements of value arising from the accomplishment or expectation of the merger and together

with interest (as described in the accompanying proxy statement) to be paid on the amount determined to be “fair value”) in lieu of receiving $20.42 in cash, without interest thereon and subject to any withholding of taxes, and one (1) contractual contingent value right per share of common stock if the merger is completed, as determined in accordance with Section 262 of the General Corporation Law of the State of Delaware (which we refer to as the “DGCL”). To do so, a Landos record stockholder or beneficial owner must properly demand appraisal before the vote is taken on the Merger Agreement and comply with all other requirements of the DGCL, including Section 262 of the DGCL, which are summarized in the accompanying proxy statement, and certain conditions set forth in Section 262(g) of the DGCL must be satisfied. A copy of Section 262 of the DGCL is accessible, without subscription or cost, at the following publicly available website: https://delcode.delaware.gov/title8/c001/sc09/index.html#262 and is incorporated by reference herein.

The enclosed proxy statement provides detailed information about the Special Meeting, the Merger Agreement, the Merger and the CVR Agreement. A copy of the Merger Agreement is attached as Annex A to the proxy statement (including the form of CVR Agreement which is an exhibit to the Merger Agreement).

The proxy statement also describes the actions and determinations of the Board of Directors in connection with its evaluation of the Merger Agreement and the Merger. You should carefully read and consider the entire enclosed proxy statement and its annexes, including, but not limited to, the Merger Agreement, as they contain important information about, among other things, the Merger and how it affects you.

Whether or not you plan to attend the Special Meeting virtually, please sign, date and return, as promptly as possible, the enclosed proxy card in the accompanying prepaid reply envelope or grant your proxy electronically over the Internet or by telephone (using the instructions provided in the enclosed proxy card). If you attend the Special Meeting and vote at the meeting your vote will revoke any proxy that you have previously submitted.

If you hold your shares in “street name,” you should instruct your bank, broker or other nominee how to vote your shares in accordance with the voting instruction form that you will receive from your bank, broker or other nominee. Your bank, broker or other nominee cannot vote on any of the proposals, including the proposal to adopt the Merger Agreement, without your instructions.

Your vote is very important, regardless of the number of shares that you own. We cannot complete the Merger unless the proposal to adopt the Merger Agreement is approved by the affirmative vote of the holders of a majority of the shares of Landos’ common stock that are issued and outstanding as of the close of business on     , 2024 , which is the record date for the Special Meeting.

If you have any questions or need assistance voting your shares, please contact our proxy solicitor:

MacKenzie Partners, Inc.

1407 Broadway, 27^th Floor

New York, New York 10018

(212) 929-5500 (Call Collect)

Or

Call Toll-Free (800) 322-2885

Email: proxy@mackenziepartners.com

On behalf of the Board of Directors, I thank you for your support and appreciate your consideration of this matter.

Sincerely,

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of the Merger, passed upon the merits or fairness of the Merger Agreement or the transactions contemplated thereby, including the proposed Merger, or passed upon the adequacy or accuracy of the information contained in the accompanying proxy statement. Any representation to the contrary is a criminal offense.

PRELIMINARY PROXY STATEMENT—SUBJECT TO COMPLETION, DATED APRIL 15, 2024

Landos Biopharma, Inc.

P.O. Box 11239

Blacksburg, Virginia 24062

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

TO BE HELD ON     , 2024

Notice is hereby given that a virtual special meeting of stockholders (including any adjournments or postponements thereof, the “Special Meeting”) of Landos Biopharma, Inc., a Delaware corporation (“Landos”), to be held virtually on     , 2024, at     Eastern Time via live audio webcast on the Internet at www.virtualshareholdermeeting.com/LABP2024SM, for the following purposes:

Only stockholders of record as of the close of business on     , 2024, are entitled to notice of the Special Meeting and to vote at the Special Meeting or any adjournment, postponement or other delay thereof.

Landos’ Board of Directors (the “Board of Directors”) unanimously recommends, on behalf of Landos, that you vote (1) “FOR” the adoption of the Merger Agreement and (2) “FOR” the Adjournment Proposal.

All stockholders are invited to attend the Special Meeting virtually. Whether or not you plan to attend the Special Meeting virtually, please sign, date and return, as promptly as possible, the enclosed proxy card in the accompanying prepaid reply envelope or grant your proxy electronically over the Internet or by telephone (using the instructions provided in the enclosed proxy card). If you attend the Special Meeting and vote virtually, your vote will revoke any proxy that you have previously submitted. If you hold your shares in “street name,” you should instruct your bank, broker or other nominee how to vote your shares in accordance with the voting instruction form that you will receive from your bank, broker or other nominee. Your bank, broker or other nominee cannot vote on any of the proposals, including the proposal to adopt the Merger Agreement, without your instructions.

    , 2024

PRELIMINARY PROXY STATEMENT—SUBJECT TO COMPLETION, DATED APRIL 15, 2024

LANDOS BIOPHARMA, INC.

P.O. Box 11239

Blacksburg, Virginia 24062

NOTICE OF SPECIAL MEETING OF STOCKHOLDERS

TO BE HELD VIRTUALLY VIA WEBCAST ON    , 2024

This proxy statement is available on the investor relations page of our website at https://ir.landosbiopharma.com/sec-filings. We intend to mail these proxy materials on or about    , 2024 to all stockholders of record entitled to vote at the Special Meeting.

A complete list of the stockholders entitled to vote at the Special Meeting will be available for examination for the ten (10) days prior to the Special Meeting. To access the list of record stockholders, stockholders should email info@landosbiopharma.com. Stockholders may examine the list for any legally valid purpose related to the Special Meeting. This list also will be available during the Special Meeting at www.virtualshareholdermeeting.com/LABP2024SM.

YOUR VOTE IS IMPORTANT

WHETHER OR NOT YOU PLAN TO ATTEND THE SPECIAL MEETING VIRTUALLY, WE ENCOURAGE YOU TO SUBMIT YOUR PROXY AS PROMPTLY AS POSSIBLE: (1) BY TELEPHONE; (2) THROUGH THE INTERNET; OR (3) BY SIGNING AND DATING THE ENCLOSED PROXY CARD AND RETURNING IT IN THE POSTAGE-PAID ENVELOPE PROVIDED. You may revoke your proxy or change your vote at any time before it is voted at the Special Meeting.

If you hold your shares in “street name,” you should instruct your bank, broker or other nominee how to vote your shares in accordance with the voting instruction form that you will receive from your bank, broker or other nominee. Your broker or other agent cannot vote on any of the proposals, including the proposal to adopt the Merger Agreement, without your instructions.

If you are a stockholder of record, meaning that your Landos shares are registered in your name directly with Landos’ transfer agent, voting virtually at the Special Meeting will revoke any proxy that you previously submitted. If you hold your shares through a bank, broker or other nominee, you must obtain a “legal proxy” in order to vote virtually at the Special Meeting.

If you fail to (1) return your proxy card, (2) grant your proxy electronically over the Internet or by telephone or (3) vote virtually at the Special Meeting, your shares will not be counted for purposes of determining whether a quorum is present at the Special Meeting and, if a quorum is present, will have the same effect as a vote “AGAINST” the proposal to adopt the Merger Agreement, but will have no effect on the Adjournment Proposal (as defined below).

You should carefully read and consider the entire accompanying proxy statement and its annexes, including, but not limited to, the Merger Agreement as they contain important information about, among other things, the Merger and how it affects you. If you have any questions concerning the Merger Agreement, the Merger, the

Special Meeting or the accompanying proxy statement, would like additional copies of the accompanying proxy statement or need help voting your shares of common stock, please contact our proxy solicitor:

MacKenzie Partners, Inc.

1407 Broadway, 27^th Floor

New York, New York 10018

(212) 929-5500 (Call Collect)

Or

Call Toll-Free (800) 322-2885

Email: proxy@mackenziepartners.com

TABLE OF CONTENTS

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QUESTIONS AND ANSWERS

The following questions and answers address some commonly asked questions regarding the Merger, the Merger Agreement, the CVR Agreement and the Special Meeting. These questions and answers may not address all questions that are important to you. You should carefully read and consider the more detailed information contained elsewhere in this proxy statement and the annexes to this proxy statement, including, but not limited to, the Merger Agreement, along with all of the documents we refer to in this proxy statement, as they contain important information about, among other things, the Merger and how it affects you.

Beneficial stockholders whose shares are held by a broker, bank or other nominee and who do not have a control number may gain access to the meeting by logging into their brokerage firm’s website and selecting the stockholder communications mailbox to link through to the Special Meeting; instructions should also be provided on the voting instruction card provided by their broker, bank, or other nominee.

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We encourage you to access the Special Meeting before it begins. Online check-in will start approximately fifteen (15) minutes before the Special Meeting is scheduled to begin at   Eastern Time on  , 2024.

Each holder of record of common stock shall be entitled to cast one (1) vote on each matter properly brought before the Special Meeting for each such share owned at the close of business on the Record Date.

Attending the Special Meeting as a Guest. Guests may enter the Special Meeting in “listen-only” mode by entering the Special Meeting at www.virtualshareholdermeeting.com/LABP2024SM and entering the information requested in the “Guest Login” section. Guests will not have the ability to vote or ask questions at the Special Meeting.

(i) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is less than or equal to the Closing Amount will be cancelled and converted into the right to receive (A) an amount in cash, without interest, equal to the product of (1) the excess, if any, of the Closing Amount over the exercise price per share of common stock of such Landos Option, multiplied by (2) the number of shares of common stock then subject to such Landos Option and (B) one (1) CVR for each share of common stock subject to such Landos Option;

(ii) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is greater than the Closing Amount will be cancelled without any consideration being payable in respect thereof, and have no further force or effect; and

(iii) Landos RSU that is unvested and outstanding as of immediately prior to the Effective Time will fully vest, be cancelled and converted into the right to receive (A) an amount in cash, without interest, in respect thereof equal to the Closing Amount multiplied by the number of shares of common stock subject to such Landos RSU and (B) one (1) CVR.

For more information, please see the section of this proxy statement captioned “Proposal 1: Adoption of the Merger Agreement—Closing Amount—Treatment of Landos Options and Landos RSUs.”

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The “Applicable Closing Price” is equal to the Closing Sale Price (as defined in the Landos Warrants) per share of our common stock as of the Trading Day (as defined in the Landos Warrants) on the date immediately preceding the Closing Date.

For more information, please see the section of this proxy statement captioned “Proposal 1: Adoption of the Merger Agreement—Closing Amount—Treatment of Landos Warrants.”

As of the close of business on     , 2024, the Record Date for the Special Meeting, there were      shares of common stock outstanding.

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If a quorum is present at the Special Meeting, the failure of any stockholder of record to: (i) submit a signed proxy card; (ii) grant a proxy over the Internet or by telephone (using the instructions provided in the enclosed proxy card); or (iii) vote virtually at the Special Meeting will have the same effect as a vote “AGAINST” the proposal to adopt the Merger Agreement. If you hold your shares in “street name” and a quorum is present at the Special Meeting, the failure to instruct your bank, broker or other nominee how to vote your shares will have the same effect as a vote “AGAINST” the proposal to adopt the Merger Agreement. If a quorum is present at the Special Meeting, abstentions will have the same effect as a vote “AGAINST” the proposal to adopt the Merger Agreement.

If a stockholder abstains from voting on the Adjournment Proposal, that abstention will have the same effect as if the stockholder voted “AGAINST” the proposal to adopt the Adjournment Proposal. However, abstentions are counted for purposes of determining whether a quorum is present at the Special Meeting. As a result, an abstention of any of the aforementioned proposals will be counted for purposes of determining the presence or absence of a quorum but will count as a vote “AGAINST” such proposal.

We do not expect any “broker non-votes” at the Special Meeting, but if there are any, they will be counted for the purpose of determining whether a quorum is present. If there are “broker non-votes,” such “broker non-votes” will have no effect on the Adjournment Proposal.

Failure to vote your shares of common stock (including a failure of your broker, bank or other nominee to vote shares held on your behalf) will also count as a vote “AGAINST” the proposal to adopt the Merger

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Agreement. If your shares are not deemed present or represented by proxy at the Special Meeting, then a failure to vote will not have any effect on the Adjournment Proposal. If your shares are deemed present or represented by proxy, then a failure to vote your shares will have the same effect as a vote “AGAINST” the Adjournment Proposal only if a quorum is not present, and, if a quorum is present, will have no effect on the Adjournment Proposal.

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If your shares are held through a bank, broker or other nominee, you are considered the “beneficial owner” of shares of common stock held in “street name.” In that case, this proxy statement has been forwarded to you by your bank, broker or other nominee who is considered, with respect to those shares, to be the stockholder of record. As the beneficial owner, you have the right to direct your bank, broker or other nominee how to vote your shares by following their instructions for voting. You are also invited to attend the Special Meeting. However, because you are not the stockholder of record, you may not vote your shares virtually at the Special Meeting.

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A control number, located on your proxy card, is designed to verify your identity and allow you to vote your shares of common stock, and to confirm that your voting instructions have been properly recorded when voting electronically over the Internet or by telephone (using the instructions provided in the enclosed proxy card). Please be aware that, although there is no charge for voting your shares, if you vote electronically over the Internet or by telephone, you may incur costs such as Internet access and telephone charges for which you will be responsible.

Even if you plan to attend the Special Meeting virtually, you are strongly encouraged to vote your shares of common stock by proxy. If you are a record holder or if you obtain a “legal proxy” to vote shares that you beneficially own, you may still vote your shares of common stock virtually at the Special Meeting even if you have previously voted by proxy. If you are present at the Special Meeting and vote virtually, your previous vote by proxy will not be counted.

If your shares are held in “street name” through a bank, broker or other nominee, you may vote through your bank, broker or other nominee by completing and returning the voting form provided by your bank, broker or other nominee, or, if such a service is provided by your bank, broker or other nominee, electronically over the Internet or by telephone. To vote over the Internet or by telephone through your bank, broker or other nominee, you should follow the instructions on the voting form provided by your bank, broker or nominee.

If you hold your shares of common stock in “street name,” you should contact your bank, broker or other nominee for instructions regarding how to change your vote. You may also vote virtually at the Special Meeting if you obtain a “legal proxy” from your bank, broker or other nominee.

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If you properly sign your proxy card but do not mark the boxes showing how your shares should be voted on a matter, the shares represented by your properly signed proxy will be voted (i) “FOR” the adoption of the Merger Agreement and (ii) “FOR” the approval of the Adjournment Proposal.

You may receive more than one (1) set of voting materials, including multiple copies of this proxy statement and multiple proxy cards or voting instruction cards. For example, if you hold your shares in more than one (1) brokerage account, you will receive a separate voting instruction card for each brokerage account in which you hold shares. If you are a stockholder of record and your shares are registered in more than one (1) name, you will receive more than one (1) proxy card.

MacKenzie Partners, Inc.

1407 Broadway, 27^th Floor

New York, New York 10018

(212) 929-5500 (Call Collect)

Or

Call Toll-Free (800) 322-2885

Email: proxy@mackenziepartners.com

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FORWARD-LOOKING STATEMENTS

This proxy statement contains forward-looking statements which involve substantial risks and uncertainties and are based on Landos’ beliefs and assumptions and on information currently available to Landos. All statements other than statements of historical facts contained in this proxy statement, including statements regarding the Transactions, are forward-looking statements. These forward-looking statements are subject to the safe harbor provisions under the Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements because they contain words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” or “would,” or the negative of these words or other similar terms or expressions.

Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Forward-looking statements represent our current beliefs, estimates and assumptions only as of the date of this proxy statement and information contained in this proxy statement should not be relied upon as representing Landos’ estimates as of any subsequent date. These statements, and related risks, uncertainties, factors and assumptions, include, but are not limited to:

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In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based on information available to us as of the date of this proxy statement. While we believe that information provides a reasonable basis for these statements, that information may be limited or incomplete. Our statements should not be read to indicate that we have conducted an exhaustive inquiry into, or review of, all relevant information. These statements are inherently uncertain, and investors are cautioned not to unduly rely on these statements as predictions of future events.

These risks are not exhaustive. Except as required by law, Landos assumes no obligation to update these forward-looking statements, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future. Further information on factors that could cause actual results to differ materially from the results anticipated by Landos’ forward-looking statements is included in the reports Landos has filed or will file with the SEC, including Landos’ Annual Report on Form 10-K for the year ended December 31, 2023, and subsequent filings Landos makes with the SEC. These filings, when available, are available on the investor relations section of Landos’ website at https://ir.landosbiopharma.com and on the SEC’s website at www.sec.gov.

Stockholders are advised to consult any future disclosures that we make on related subjects as may be detailed in our other filings made from time to time with the SEC.

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THE SPECIAL MEETING

The enclosed proxy is solicited on behalf of the Board of Directors for use at the Special Meeting.

Date, Time and Place

We will hold the Special Meeting virtually on    , 2024 at    Eastern Time via the live audio webcast on the Internet at www.virtualshareholdermeeting.com/LABP2024SM and, if applicable, at any adjournment or postponement thereof.

Purpose of the Special Meeting

At the Special Meeting, we will ask stockholders to vote on proposals to (i) adopt the Merger Agreement and (ii) approve the Adjournment Proposal.

We do not expect that any matters other than the proposals set forth above will be brought before the Special Meeting, and only matters specified in the notice of the meeting may be acted upon at the Special Meeting.

Our stockholders must approve the proposal to adopt the Merger Agreement in order for the Merger to be consummated. If our stockholders fail to approve the proposal to adopt the Merger Agreement, the Merger will not be consummated. A copy of the Merger Agreement is attached as Annex A to this proxy statement, which we urge you to read carefully in its entirety.

Record Date; Shares Entitled to Vote; Quorum

Only stockholders of record as of the Record Date are entitled to notice of the Special Meeting and to vote at the Special Meeting. For the ten days ending the day prior to the Special Meeting, a list of stockholders entitled to vote at the Special Meeting will be available to stockholders and will be available electronically at the Special Meeting. To access the list of record stockholders, stockholders should email info@landosbiopharma.com.

The holders of a majority of the stock issued and outstanding and entitled to vote thereat, present virtually or represented by proxy, will constitute a quorum at the Special Meeting. As of the Record Date, there were      shares of common stock outstanding and entitled to vote at the Special Meeting, meaning that      shares of common stock must be represented virtually or by proxy at the Special Meeting to have a quorum. In the event that a quorum is not present at the Special Meeting, it is expected that the meeting will be adjourned to solicit additional proxies to approve the proposal to adopt the Merger Agreement.

Vote Required; Abstentions and Broker Non-Votes

The affirmative vote of the holders of a majority of the shares of common stock that are issued and outstanding as of the Record Date is required to adopt the Merger Agreement. As of the Record Date,     shares constitute a majority of the outstanding shares of common stock. Adoption of the Merger Agreement by stockholders is a condition to the Closing.

Approval of the Adjournment Proposal requires either (i) if a quorum is present, the affirmative vote of the majority of the shares present in person, by remote communication, if applicable, or represented by proxy duly authorized at the Special Meeting and entitled to vote generally on the subject matter or (ii) if a quorum is not present, the vote of the holders of a majority of the shares represented at the Special Meeting. Assuming the Special Meeting is held solely by means of remote communication, as it is currently scheduled to be, no shares will be present in person at the Special Meeting, and only shares present virtually or represented by proxy at the Special Meeting will be able to be voted.

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An abstention represents a stockholder’s affirmative choice to decline to vote on a proposal. If a stockholder abstains from voting, that abstention will have the same effect as if the stockholder voted “AGAINST” the proposal to adopt the Merger Agreement and the Adjournment Proposal. However, abstentions are counted for purposes of determining whether a quorum is present at the Special Meeting. As a result, an abstention of any of the aforementioned proposals will be counted for purposes of determining the presence or absence of a quorum, but will count as a vote “AGAINST” such proposal.

A “broker non-vote” generally occurs when a bank, broker or other nominee holding shares on your behalf does not vote on a proposal because the bank, broker or other nominee has not received your voting instructions and lacks discretionary power to vote the shares. We do not expect any “broker non-votes” at the Special Meeting, but if there are any, they will be counted for the purpose of determining whether a quorum is present. If there are “broker non-votes,” each broker non-vote will have the same effect as a vote “AGAINST” the proposal to adopt the Merger Agreement, but any such “broker non-votes” will have no effect on the Adjournment Proposal.

Shares Held by Landos’ Directors and Executive Officers

As of the Record Date, our directors and executive officers beneficially owned and were entitled to vote, in the aggregate,    shares of common stock, representing approximately % of the shares of common stock outstanding on the Record Date (and approximately % of the shares of common stock outstanding when taking into account Landos Options and Landos RSUs held, in the aggregate, by our directors and executive officers).

Our directors and executive officers have informed us that they currently intend to vote all of their respective shares of common stock (i) “FOR” the adoption of the Merger Agreement and (ii) “FOR” the approval of the Adjournment Proposal.

Voting of Proxies

If, at the close of business on the Record Date, your shares are registered in your name with our transfer agent, Broadridge Corporate Issuer Solutions, Inc., on the Record Date, you may cause your shares to be voted by returning a signed and dated proxy card in the accompanying prepaid envelope, or you may vote virtually at the Special Meeting. Additionally, you may grant a proxy electronically over the Internet or by telephone (using the instructions provided in the enclosed proxy card). You must have the enclosed proxy card available, and follow the instructions on the proxy card, in order to grant a proxy electronically over the Internet or by telephone. Based on your proxy card or Internet and telephone proxies, the proxy holders will vote your shares according to your directions.

If your Landos shares are registered in your name and you plan to attend the Special Meeting and wish to vote virtually, you will need to enter the 16-digit Control Number found next to the label “Control Number” on your proxy card voting instruction form, or in the email sending you the proxy statement. If you attend the Special Meeting, and vote virtually, your vote will revoke any previously submitted proxy. If your shares are registered in your name, you are encouraged to vote by proxy even if you plan to attend the Special Meeting virtually.

Voting instructions are included on your proxy card. All shares represented by properly signed and dated proxies received in time for the Special Meeting will be voted at the Special Meeting in accordance with the instructions of the stockholder. Properly signed and dated proxies that do not contain voting instructions will be voted (i) “FOR” the adoption of the Merger Agreement and (ii) “FOR” the approval of the Adjournment Proposal.

If, at the close of business on the Record Date, your shares are held in “street name” through a bank, broker or other nominee, you may vote through your bank, broker or other nominee by completing and returning the voting form provided by your bank, broker or other nominee or attending the Special Meeting and voting

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virtually with a “legal proxy” from your bank, broker or other nominee. If such a service is provided, you may vote over the Internet or telephone through your bank, broker or other nominee by following the instructions on the voting form provided by your bank, broker or other nominee. If you do not return your bank’s, broker’s or other nominee’s voting form, do not vote via the Internet or telephone through your bank, broker or other nominee, if possible, or do not attend the Special Meeting and vote virtually with a “legal proxy” from your bank, broker or other nominee, it will have the same effect as if you voted “AGAINST” the proposal to adopt the Merger Agreement but will not have any effect on the Adjournment Proposal.

Revocability of Proxies

If you are a stockholder of record entitled to vote at the Special Meeting, you may change your vote or revoke your proxy at any time before it is voted at the Special Meeting by:

If you hold your shares of common stock in “street name,” you should contact your bank, broker or other nominee for instructions regarding how to change your vote. You may also vote virtually at the Special Meeting if you obtain a “legal proxy” from your bank, broker or other nominee.

Adjournments and Recess

Although it is not currently expected, the Special Meeting may be adjourned or recessed to a later date or dates, including for the purpose of soliciting additional proxies, if there are insufficient votes at the time of the Special Meeting to approve the proposal to adopt the Merger Agreement or if a quorum is not present at the Special Meeting. Other than an announcement to be made at the Special Meeting of the time, date and place of an adjourned meeting, an adjournment generally may be made without notice. Any adjournment or recess of the Special Meeting for the purpose of soliciting additional proxies will allow the stockholders who have already sent in their proxies to revoke them at any time prior to their use at the Special Meeting as adjourned or recessed.

Board of Directors’ Recommendation

The Board of Directors, after considering various factors described under the caption, “The Merger —Recommendation of the Board of Directors and Reasons for Recommendation of the Merger,” has unanimously (a) determined that the Transactions, including the Merger, are advisable and fair to, and in the best interests of, Landos and its stockholders; (b) authorized and approved the execution, delivery, and performance of the Merger Agreement, the CVR Agreement and the Voting Agreement by Landos and approved the Merger; (c) recommended the adoption of the Merger Agreement by Landos’ stockholders and (d) directed that the Merger Agreement be submitted for consideration by Landos’ stockholders at the Special Meeting.

Accordingly, the Board of Directors unanimously recommends, on behalf of Landos, that you vote (i) “FOR” the adoption of the Merger Agreement and (ii) “FOR” the approval of the Adjournment Proposal.

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Solicitation of Proxies

The expense of soliciting proxies will be borne by Landos. We have retained MacKenzie Partners, Inc. (“Proxy Solicitor”), a proxy solicitation firm, to solicit proxies in connection with the Special Meeting at a cost of approximately $9,500 plus expenses. We will also indemnify Proxy Solicitor against losses arising out of its provisions of these services on our behalf. In addition, we may reimburse banks, brokers and other nominees representing beneficial owners of shares for their expenses in forwarding soliciting materials to such beneficial owners. Proxies may also be solicited by our directors, officers and employees, personally or by telephone, email, fax, over the Internet or other means of communication. No additional compensation will be paid for such services.

Anticipated Date of Completion of the Merger

Assuming timely satisfaction of necessary closing conditions, including obtaining the Required Company Stockholder Vote, Landos is currently targeting to consummate the Merger in the first half of 2024, although Landos cannot assure completion by any particular date, if at all. Since the Merger is subject to a number of conditions, the exact timing of the Merger cannot be determined at this time.

Appraisal Rights

If the Merger is consummated, Landos stockholders (including beneficial owners of shares of capital stock) who (1) do not vote in favor of the adoption of the Merger Agreement; (2) continuously hold their shares through the Effective Time; (3) properly perfect appraisal of their shares; (4) meet certain other conditions and statutory requirements described in this proxy statement; and (5) do not withdraw their demands or otherwise lose their rights to appraisal will be entitled to seek appraisal of their shares in connection with the Merger under Section 262 of the DGCL if certain conditions set forth in Section 262(g) of the DGCL are satisfied. This means that such persons will be entitled to seek appraisal of their shares by the Delaware Court of Chancery and to receive payment in cash of the “fair value” of their shares of Landos common stock, exclusive of any elements of value arising from the accomplishment or expectation of the Merger, together with (unless the Delaware Court of Chancery in its discretion determines otherwise for good cause shown) interest on the amount determined by the Delaware Court of Chancery to be the fair value from the effective date of the Merger through the date of payment of the judgment at a rate of five percent over the Federal Reserve discount rate (including any surcharge) as established from time to time during the period between the Effective Time and the date of payment of the judgment, compounded quarterly (except that, if at any time before the entry of judgment in the proceeding, the Surviving Corporation makes a voluntary cash payment to each person entitled to appraisal, interest will accrue thereafter only upon the sum of (x) the difference, if any, between the amount so paid and the fair value of the shares as determined by the Delaware Court of Chancery; and (y) interest theretofore accrued, unless paid at that time). The Surviving Corporation is under no obligation to make such voluntary cash payment prior to such entry of judgment. Due to the complexity of the appraisal process, persons who wish to seek appraisal of their shares are encouraged to seek the advice of legal counsel with respect to the exercise of appraisal rights.

Persons considering seeking appraisal should be aware that the fair value of shares as determined pursuant to Section 262 of the DGCL could be more than, the same as or less than the value of the consideration that they would receive pursuant to the Merger Agreement if they did not seek appraisal of their shares.

To exercise appraisal rights, the stockholder of record or a beneficial owner must (1) submit a written demand for appraisal to Landos before the vote is taken on the proposal to adopt the Merger Agreement; (2) not vote, in person by attending via live audio webcast or by proxy, in favor of the proposal to adopt the Merger Agreement; (3) continue to hold of record or own beneficially the subject shares of Landos common stock through the Effective Time; and (4) strictly comply with all other procedures for exercising appraisal rights under the DGCL. The failure to follow exactly the procedures specified under the DGCL may result in the loss of appraisal rights. In addition, the Delaware

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Court of Chancery will dismiss appraisal proceedings in respect of Landos unless certain conditions are satisfied by the persons seeking appraisal. The requirements under Section 262 of the DGCL for exercising appraisal rights are described in further detail in this proxy statement, which description is qualified in its entirety by Section 262 of the DGCL, the relevant section of the DGCL regarding appraisal rights. A copy of Section 262 of the DGCL is accessible, without subscription or cost, at the following publicly available website: https://delcode.delaware.gov/title8/c001/sc09/index.html#262. In the event of any inconsistency between the information contained in this summary, this proxy statement, or any of the documents incorporated herein or therein by reference, and the actual text of Section 262 of the DGCL, the actual text of Section 262 of the DGCL controls. If you hold your shares of Landos common stock through a bank, broker or other nominee and you wish to exercise appraisal rights, you should consult with your bank, broker or other nominee to determine the appropriate procedures for the making of a demand for appraisal on your behalf by your bank, broker or other nominee.

Delisting and Deregistration of Landos Common Stock

If the Merger is completed, the shares of Landos’ common stock will be delisted from Nasdaq and deregistered under the Exchange Act, and shares of Landos’ common stock will no longer be publicly traded. As such, Landos will no longer file periodic reports with the SEC on account of Landos’ common stock.

Important Notice Regarding the Availability of Proxy Materials for the Stockholder Meeting to be Held on    , 2024

The proxy statement is available on the investor relations page of our website at https://ir.landosbiopharma.com.

Questions and Additional Information

If you have any questions concerning the Merger, the Special Meeting or the accompanying proxy statement, would like additional copies of the accompanying proxy statement or need help voting your shares of common stock, please contact our proxy solicitor:

MacKenzie Partners, Inc.

1407 Broadway, 27^th Floor

New York, New York 10018

(212) 929-5500 (Call Collect)

Or

Call Toll-Free (800) 322-2885

Email: proxy@mackenziepartners.com

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THE MERGER

This discussion of the Merger is qualified in its entirety by reference to the Merger Agreement, which is attached to this proxy statement as Annex A and incorporated into this proxy statement by reference. You should carefully read and consider the entire Merger Agreement, which is the legal document that governs the Merger, because this document contains important information about the Merger and how it affects you.

Parties Involved in the Merger

Landos Biopharma, Inc.

Landos is a clinical-stage biopharmaceutical company focused on the development of novel, oral, once-daily therapeutics for patients with certain immunology diseases. Landos’ core expertise is the development of compounds that target novel pathways at the interface of immunity and metabolism. Based on Landos’ understanding of the role that cellular metabolic pathways have on modulating inflammatory responses, Landos aims to inhibit these inflammatory responses by changing the metabolic processes in target cells. Landos believes the therapeutics Landos develops, if approved, could have a significant positive impact on the quality of life of patients suffering from immunology diseases. Landos’ common stock is listed on The Nasdaq Capital Market (“Nasdaq”) under the symbol “LABP.” Landos’ current focus and lead product candidate is NX-13, a novel, oral, gut-selective, NLRX1 agonist in development as a once-daily, oral treatment for ulcerative colitis and Crohn’s disease that targets NLRX1, a mitochondria-associated receptor that has been associated with the modulation of inflammatory cytokines for ulcerative colitis and Crohn’s disease. NX-13 is designed to target NLRX1 and induce anti-inflammatory effects in CD4+ T cells as well as other cells in the gastrointestinal tract. Landos’ common stock is listed on The Nasdaq Capital Market (“Nasdaq”) under the symbol “LABP.” Landos’ executive officers and employees work remotely in a “virtual office” setting. Landos’ mailing address is P.O. Box 11239, Blacksburg, VA 24062 and its telephone number is (540) 218-2232.

AbbVie Inc.

AbbVie is a global, diversified research-based biopharmaceutical company positioned for success with a comprehensive product portfolio that has leadership positions across immunology, oncology, aesthetics, neuroscience and eye care. AbbVie uses its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world’s most complex and serious diseases. AbbVie’s portfolio of products includes immunology products, oncology products, aesthetics products, neuroscience products, eye care products and other key products. AbbVie was incorporated in State of Delaware on April 10, 2012. AbbVie’s common stock is listed and traded on the NYSE under the symbol “ABBV.” AbbVie’s principal executive offices are located at 1 North Waukegan Road, North Chicago, Illinois 60064-6400, and its telephone number is (847) 932-7900.

Bespin Subsidiary, LLC

Parent is a Delaware limited liability company and a wholly owned subsidiary of AbbVie and was formed on March 15, 2024, solely for the purpose of engaging in the transactions contemplated by the Merger Agreement. Parent has not engaged in any business activities other than in connection with the transactions contemplated by the Merger Agreement. The principal executive offices of Parent are located at 1 North Waukegan Road, North Chicago, Illinois 60064-6400, and its telephone number is (847) 932-7900.

Bespin Merger Sub, Inc.

Merger Sub is a Delaware corporation and a wholly owned subsidiary of Parent and was formed on March 15, 2024, solely for the purpose of engaging in the transactions contemplated by the Merger Agreement. Merger Sub has not engaged in any business activities other than in connection with the transactions contemplated by the Merger Agreement. Upon the completion of the Merger, Merger Sub will cease to exist and Landos will continue as the Surviving Corporation. The principal executive offices of Merger Sub are located at 1 North Waukegan Road, North Chicago, Illinois 60064-6400, and its telephone number is (847) 932-7900.

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Effect of the Merger

Upon the terms and subject to the conditions of the Merger Agreement, Merger Sub will merge with and into Landos, with Landos continuing as the Surviving Corporation. As a result of the Merger, Landos will become an indirect wholly owned subsidiary of AbbVie, and our common stock will no longer be publicly traded and will be delisted from Nasdaq. In addition, our common stock will be deregistered under the Exchange Act, and we will no longer file periodic reports with the SEC. If the Merger is completed, you will not own any shares of the capital stock of the Surviving Corporation.

The Effective Time will occur upon the filing of a certificate of merger with the Secretary of State of the State of Delaware (or at such later time as we and Parent may agree in writing and specify in the certificate of merger).

Effect on Landos if the Merger is Not Completed

If the Merger Agreement is not adopted by stockholders, or if the Merger is not completed for any other reason:

Merger Consideration

At the Effective Time, each share of common stock (other than Cancelled Shares and Dissenting Shares) outstanding as of immediately prior to the Effective Time will be cancelled and automatically converted into the right to receive (A) the Closing Amount and (B) one (1) CVR, in each case, without interest thereon and subject to any withholding of taxes.

After the Merger is completed, you will have the right to receive the Closing Amount in respect of each share of common stock that you own (subject to any withholding of taxes), but you will no longer have any rights as a stockholder (except that stockholders who properly exercise their appraisal rights will have a right to receive payment of the “fair value” of their shares as determined pursuant to an appraisal proceeding, as contemplated by Delaware law). For more information, please see the section of this proxy statement captioned “—Appraisal Rights.”

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Background of the Merger

The Board of Directors, together with Landos senior management and with the assistance of its outside advisors, frequently reviews Landos’ strategic and financial alternatives in light of developments in Landos’ business, the sectors in which it operates, and the economy and financial markets generally, as they, individually and together, may affect Landos’ long-term strategic goals and plans. As part of this process, members of Landos senior management have engaged from time to time in business development and strategic discussions with participants in the biopharmaceutical and healthcare industries, including AbbVie, all with the goal of enhancing value for Landos stockholders. These strategic discussions have focused on, among other things, opportunities for business combinations, licensing transactions, commercial agreements, asset acquisitions and divestitures and other financial and strategic alternatives for Landos, including continuing as a standalone company.

From time to time beginning in late 2021 and continuing until mid-2022, representatives of AbbVie engaged in initial technical assessments involving a potential license (or option to license) by Landos to AbbVie of NX-13 and other compounds targeting NLRX1. To facilitate these discussions, Landos and AbbVie entered into a bilateral confidential disclosure agreement on September 15, 2021 (the “AbbVie NDA”), which was later extended by an amendment on October 11, 2022 (“Amendment No. 1 to AbbVie NDA”) and again by an amendment on September 8, 2023 (“Amendment No. 2 to AbbVie NDA”) (together, the “AbbVie NDA Amendments”). The AbbVie NDA and AbbVie NDA Amendments did not contain a standstill provision.

In May of 2022, the discussions between the representatives of Landos and AbbVie progressed to include business terms indicative of a potential licensing transaction. In connection with these progressed discussions, Landos opened a virtual data room to AbbVie and its advisors, AbbVie engaged in due diligence of NX-13 and Landos, and AbbVie made various proposals to Landos relating to a licensing transaction in May 2022, January 2023 and July 2023. During the course of these discussions, the representatives of Landos regularly updated the Board of Directors and received direction from the Board of Directors regarding further discussion with AbbVie of the terms of a potential transaction. It was noted by the Board of Directors that following the consummation of Landos’ sale of its LANCL2 portfolio, including clinical compounds omilancor and LABP-104, as well as the preclinical LABP-111 compound, in February 2023, NX-13 comprised a substantial portion of Landos’ value as its sole clinical program and that as a result, entering into such a potential commercial transaction with AbbVie would leave Landos without a clinical program that was not subject to a licensing agreement with a third party. In August 2023, Landos and AbbVie ceased discussions of an option or licensing transaction with respect to NX-13, but agreed to stay in touch regarding a potential strategic transaction between the parties.

On September 22, 2023, AbbVie submitted to Landos a non-binding indication of interest for the acquisition of 100% of the outstanding share capital of Landos on a fully diluted basis for $122.5 million in cash at closing, subject to AbbVie’s completion of due diligence (the “September 22 Proposal”). A list of initial due diligence questions was attached to the proposal. The total equity value contemplated by the September 22 Proposal was equivalent to approximately $18.63 per share of Landos common stock at closing based on the current number of outstanding shares at that time on a fully diluted basis.

On September 25, 2023, the Board of Directors held a meeting with Mr. Oakes and representatives of Cooley LLP (“Cooley”), Landos’ outside legal counsel, present. The Board of Directors discussed the terms of the September 22 Proposal and Mr. Oakes reviewed with the Board of Directors the prior proposals received from AbbVie with respect to a potential licensing transaction. The Board of Directors also discussed the potential engagement of an investment bank to assist the Board of Directors in evaluating the September 22 Proposal. Representatives of Cooley reviewed with the Board of Directors the directors’ fiduciary duties, including in the context of a potential sale of the company. After discussion, the Board of Directors directed Mr. Oakes to reach out to investment banks with relevant experience in the life sciences sector and in M&A transactions to assist the Board of Directors in evaluating the September 22 Proposal. The Board of Directors also directed Mr. Oakes to indicate to AbbVie that the Board of Directors was not prepared to transact at the price contemplated by

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the September 22 Proposal, but that Landos would continue to discuss with AbbVie and respond to AbbVie’s diligence requests to determine if AbbVie would be able to propose a higher price.

Between September 27, 2023 and October 9, 2023 there were several discussions between representatives of Landos and AbbVie regarding the proposal and AbbVie’s diligence requests. During such discussions, the Landos representatives provided the Board of Directors’ message that it was not prepared to transact at the proposed price. AbbVie representatives indicated to Landos that AbbVie was still engaged and wanted to continue exploring a potential acquisition of Landos.

On October 10, 2023, the Board of Directors held a meeting with Mr. Oakes and representatives of Cooley present to discuss the engagement of a financial advisor. Representatives of Jefferies LLC (“Jefferies”) were invited to attend the meeting to discuss AbbVie’s September 22 Proposal and to allow the Board of Directors to evaluate Jefferies’ experience and capabilities relevant to a potential strategic transaction. Mr. Oakes and Mr. Garabedian reviewed their discussions with representatives of AbbVie since the September 25 meeting of the Board of Directors. Representatives of Jefferies then reviewed Jefferies’ perspectives on the current biopharmaceutical market environment and the September 22 Proposal. The Board of Directors agreed to meet later in the week to consider the engagement of Jefferies. The Board of Directors also directed Mr. Oakes to contact representatives of AbbVie to indicate that the Board of Directors would soon conclude its discussions regarding retaining a financial advisor.

On October 12, 2023, at the direction of the Board of Directors, Mr. Oakes contacted a representative of AbbVie to deliver the message directed by the Board of Directors.

On October 13, 2023, the Board of Directors held a meeting with Landos senior management and representatives of Cooley present to discuss engaging Jefferies as Landos’ financial advisor in connection with a potential strategic transaction. In considering this decision, the Board of Directors reviewed the proposed terms of an engagement letter proposed by Jefferies with respect to Jefferies’ engagement to act as Landos’ financial advisor in connection with a potential strategic transaction and a copy of Jefferies’ customary relationship disclosures regarding its relationships in the past two years with AbbVie and certain stockholders of Landos, Xontogeny, LLC and funds affiliated with Perceptive Advisors LLC, which had been provided by Jefferies at the request of the Board of Directors on October 10, 2023. The Board of Directors considered Jefferies’ qualifications, experience and reputation in the biopharmaceutical industry and in connection with strategic transactions involving public companies, and noted that Jefferies is an internationally recognized investment banking firm. After discussing the foregoing, the Board of Directors determined to engage Jefferies as its financial advisor. Later that day, Landos entered into an engagement letter with Jefferies.

On October 16, 2023, the Board of Directors held a meeting with Mr. Oakes and representatives of Cooley present to review the October Preliminary Projections (as defined in the section titled “Certain Financial Projections”) prepared by Landos senior management. The Board of Directors and Mr. Oakes discussed the various assumptions, opportunities, risks, challenges and uncertainties inherent in Landos’ business and the October Preliminary Projections, including the appropriate probabilities of success to ascribe to NX-13 with respect to ulcerative colitis and Crohn’s disease in light of the experience and expertise with drug development of members of the Board of Directors. The Board of Directors directed Landos senior management to instruct Jefferies to use the October Preliminary Projections in its preliminary financial analysis and determined to continue to discuss the various assumptions, opportunities, risks, challenges and uncertainties inherent in Landos’ business and the October Preliminary Projections in connection with any subsequent consideration of a strategic transaction.

On October 17, 2023, the Board of Directors held a meeting with Mr. Oakes and representatives of Jefferies and Cooley present. Representatives of Jefferies presented Jefferies’ preliminary financial analyses with respect to the September 22 Proposal, taking into account the October Preliminary Projections as directed by the Board

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of Directors. Following Jefferies’ presentation of its preliminary financial analyses, the Board of Directors engaged in further discussion with representatives of Cooley and Jefferies regarding AbbVie’s September 22 Proposal and potential responses, including indicating that the price contemplated by the September 22 Proposal did not represent a basis on which the Board of Directors would be willing to transact, proposing that AbbVie increase the up-front valuation in AbbVie’s offer and suggesting the addition of CVRs to secure potential additional value for the stockholders of Landos subject to achievement of certain future milestones. The Board of Directors then directed Jefferies to contact AbbVie to indicate that the Board of Directors was not prepared to transact at the value of the current offer and that Landos was focused on executing its standalone plan, which was fully funded through the readout of data from the ongoing Phase 2 clinical trial of NX-13.

On October 18, 2023, representatives of Jefferies contacted representatives of AbbVie to convey the Board of Directors’ feedback on the September 22 Proposal. At Jefferies’ request, the representatives of Jefferies and AbbVie agreed to arrange a meeting to discuss Landos’ pre-clinical pipeline and operating costs.

On October 26, 2023, representatives of Jefferies and a representative of AbbVie held such call to discuss AbbVie’s due diligence calls regarding Landos’ pre-clinical pipeline and operating costs and to facilitate arrangement of follow-up due diligence calls regarding the same.

Also on October 26, 2023, Landos and AbbVie entered into an amendment to the AbbVie NDA, which included an extension of the term of the AbbVie NDA and a standstill provision (with customary exclusions, including a fall-away provision).

On November 3, 2023, AbbVie submitted to Landos a revised non-binding indication of interest for the acquisition of 100% of the outstanding share capital of Landos on a fully diluted basis for $122.5 million in cash at closing plus one CVR per share of Landos common stock representing the right to receive an aggregate contingent payment of $75 million, payable upon initiation of the first dosing of the first human subject, prior to December 31, 2028, in a Phase 3 registrational trial for a product containing NX-13 for ulcerative colitis (the “November 3 Proposal”). The total equity value contemplated by the November 3 Proposal was equivalent to approximately $18.63 per share of Landos common stock at closing and approximately $11.09 per share of Landos common stock with respect to the nominal value of the CVR based on the total number of outstanding shares at that time on a fully diluted basis. The November 3 Proposal stipulated that the direction of the research, development, clinical trial process and regulatory approval for such a product would be in AbbVie’s sole discretion.

Later that day, representatives of Jefferies and a representative of AbbVie held a call to discuss the November 3 Proposal, during which call the AbbVie representative indicated that he would need to hear back quickly in order to continue to devote resources to evaluating the potential transaction.

On November 6, 2023, the Board of Directors met with Mr. Oakes and representatives of Jefferies and Cooley present to discuss the November 3 Proposal. Representatives from Jefferies reviewed the November 3 Proposal, including Jefferies’ preliminary financial analyses with respect to the November 3 Proposal, taking into account the October Preliminary Projections, and informed the Board of Directors that AbbVie had indicated that it would need to hear back quickly in order to continue to devote resources to evaluating the potential transaction. The Board of Directors discussed potential responses to AbbVie and Landos’ outlook as a standalone company in the absence of a strategic transaction. After discussion, as part of the negotiations, the Board of Directors directed Jefferies to indicate to AbbVie that the upfront price per share would need to be comfortably above $20.00 per share for the Board of Directors to consider a potential transaction at that time. The Board of Directors also directed Jefferies to advocate for a commitment by AbbVie to use commercially reasonable efforts to achieve the milestone under the CVR, a longer timeline for achieving the milestone under the CVR and an expansion of the milestone trigger under the CVR to include a Phase 3 clinical trial for Crohn’s disease, in addition to such a trial for ulcerative colitis. The next day representatives of Jefferies relayed the Board’s message to representatives of AbbVie.

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On November 13, 2023, a representative of AbbVie reached out to a representative of Jefferies to indicate that AbbVie would be willing to increase the total aggregate up-front payment to $137.5 million and extend the expiration date of the Milestone by three months to March 31, 2029 (the “November 13 Proposal”). A representative of AbbVie indicated that the terms of the November 13 proposal were otherwise the same as the terms of the November 3 Proposal. The total equity value contemplated by the November 13 Proposal was equivalent to approximately $20.85 per share of Landos common stock at closing and approximately $11.38 per share of Landos common stock with respect to the nominal value of the CVR based on the total number of outstanding shares at that time on a fully diluted basis. The representative of AbbVie indicated that this proposal would be confirmed in writing via delivery of draft transaction documents later that week and that AbbVie desired to finalize all transaction documents by November 30, 2023 to be in a position to publicly announce a transaction by early December 2023.

Later that day, the Board of Directors met with Mr. Oakes and representatives of Jefferies and Cooley present. Mr. Oakes and the representatives of Jefferies and Cooley reviewed the updates reflected in the November 13 Proposal, including Jefferies’ preliminary financial analyses with respect to the November 13 Proposal, taking into account the October Preliminary Projections, and AbbVie’s proposed timeline to signing transaction documents and announcing a transaction. The Board of Directors discussed the November 13 Proposal and the potential benefits and risks of outreach to additional potential acquirers with the November 13 Proposal in-hand, and whether any third parties could reasonably be expected to have both financial ability and strategic interest in a potential transaction with Landos at this time, including third parties that from time to time had previously expressed interest in Landos’ business. The Board of Directors noted that Landos had regularly engaged in discussions with large pharmaceutical companies in the ordinary course and had gauged the interest of many of these companies in a potential strategic transaction with Landos in the preceding months, and discussed that such companies had generally indicated that they would not be interested in a potential strategic transaction with Landos until after top-line results from the Phase 2 trial for NX-13 became available. The Board of Directors further discussed that AbbVie had already conducted significant diligence and that other potential acquirors would require significant time in order to conduct diligence and potentially formulate a proposal if they were interested in doing so. The Board of Directors discussed that such a delay might risk AbbVie’s interest in acquiring Landos on the currently proposed terms or at all in light of AbbVie’s prior indications regarding timing and that it would need to hear back quickly in order to continue to devote resources to evaluating the potential transaction. Following this discussion, the Board of Directors determined not to conduct outreach to third parties regarding a potential acquisition of Landos at that time.

On November 14, 2023, a representative of AbbVie sent representatives of Jefferies an email attaching initial drafts of the Merger Agreement and CVR Agreement, noting that these agreements reflected AbbVie’s “best-and-final offer” regarding up-front price and CVR value and reiterating AbbVie’s desire to be ready to finalize transaction agreements by November 30, 2023. The draft Merger Agreement proposed, among other things, structuring the transaction as a one-step merger to be approved at a special meeting of Landos’ stockholders and a termination fee payable by Landos equal to $8,500,000, or approximately 4.0% of the total transaction value. The draft CVR Agreement generally reflected the terms of the November 13 Proposal, including that there was no obligation for AbbVie to use commercially reasonable efforts to achieve the CVR milestone.

On November 18, 2023, following discussions between representatives of Cooley and members of the Board of Directors, Cooley sent revised drafts of the Merger Agreement and CVR Agreement to AbbVie’s outside legal counsel at Paul, Weiss, Rifkind, Wharton & Garrison LLP (“Paul Weiss”). The draft Merger Agreement proposed, among other things, structuring the transaction as a tender offer followed by a second-step merger and a termination fee payable by Landos equal to 2.75% of the total transaction value. The draft of the CVR Agreement included, among other things, an obligation for AbbVie to use commercially reasonable efforts to achieve the CVR milestone.

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Later on November 18, 2023, a representative of Paul Weiss called a representative of Cooley to review AbbVie’s initial feedback to the markups of the Merger Agreement and CVR Agreement sent by Cooley earlier that day.

On November 19, 2023, representatives of Jefferies, Mr. Oakes and a representative of AbbVie held a call to review AbbVie’s initial feedback to the markups of the Merger Agreement and CVR Agreement sent by Cooley the prior day.

On November 20, 2023, the Board of Directors met with Mr. Oakes and representatives of Jefferies and Cooley present. The representatives of Jefferies reviewed its preliminary financial analyses of the November 13 Proposal, taking into account the October Preliminary Projections, which Jefferies had previously presented at the November 13 meeting of the Board of Directors. The Board of Directors continued its discussion from the October 16 and October 17 meetings of the various assumptions, opportunities, risks, challenges and uncertainties inherent in Landos’ business and the October Preliminary Projections and discussed certain changes to the October Preliminary Projections, including the appropriate probabilities of success to ascribe to NX-13 for treatment of ulcerative colitis and Crohn’s disease based on review of certain market and empirical data with respect to the probability of success to FDA approval for drug candidates in the ulcerative colitis and Crohn’s disease indications, applicable scientific literature and the experience and expertise with drug development of members of the Board of Directors, as further described in the section titled “Certain Financial Projections”. After discussion, the Board of Directors directed Jefferies to use the Management Projections (as defined in the section titled “Certain Financial Projections”) in subsequent financial analyses. Mr. Oakes and the representatives of Cooley updated the Board of Directors on the current progress of diligence and the negotiations of the terms of the draft Merger Agreement and CVR Agreement, including the initial feedback received during the November 18 and November 19 discussions. After discussion, the Board of Directors determined that the terms of the November 13 Proposal represented a basis on which Landos and its advisors should continue to engage in discussions with AbbVie regarding the potential transaction, and gave direction to Cooley for continuing to negotiate the transaction terms and responding to the initial feedback provided by AbbVie and Paul Weiss on Cooley’s markups of the draft transaction agreements. From this time until the entry into the Merger Agreement and finalization of the CVR Agreement, representatives of Cooley continued to negotiate the terms of the draft agreements on behalf of Landos based on the direction of the Board of Directors.

On November 27, 2023, the Board of Directors met with Mr. Oakes and representatives of Jefferies and Cooley. Mr. Oakes and the representatives of Cooley reviewed the status of the negotiation of the draft transaction agreements and AbbVie’s due diligence. Representatives of Jefferies reviewed a revised preliminary financial analysis of the November 13 Proposal, which took into account the Management Projections (as defined in the section titled “Certain Financial Projections”) as directed by the Board of Directors. Representatives of Cooley then reviewed the terms that remained under negotiation in the draft transaction agreements and the Board of Directors gave direction based on this discussion. Mr. Oakes and representatives of Cooley reviewed the status of AbbVie’s due diligence, indicating that AbbVie had requested to schedule due diligence calls.

Beginning on December 4, 2023, representatives of Landos and Cooley and certain former employees of Landos conducted due diligence calls with representatives of AbbVie and Paul Weiss and responded to supplemental diligence requests from AbbVie. Landos continued to engage in due diligence calls at AbbVie’s request and respond to AbbVie’s supplemental diligence requests until shortly prior to the entry into the Merger Agreement and finalization of the CVR Agreement.

On December 6, 2023, Paul Weiss sent Cooley an initial draft of a Voting Agreement. Cooley sent to Paul Weiss revisions to the Voting Agreement on December 7, 2023, and followed up on December 11, 2023 with an incremental draft of the Voting Agreement reflecting comments from Xontogeny, LLC and Perceptive Advisors LLC. Representatives of Cooley and such stockholders negotiated the terms of such Voting Agreement, including with respect to, among other things, the termination provisions applicable to the Voting Agreement, the ability of the Landos stockholders signatory thereto to transfer their shares of Landos stock to their respective affiliates and the scope of the obligations of Xontogeny, LLC and Perceptive Advisors LLC to vote their shares in favor of the adoption of the Merger Agreement.

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On December 20, 2023, a representative of AbbVie indicated to Mr. Oakes that AbbVie’s due diligence process remained ongoing and that, in light of the upcoming holidays, AbbVie would intend to resume its due diligence process during January 2024.

On December 21, 2023, the Board of Directors met with Mr. Oakes and representatives of Cooley present. Mr. Oakes and the representatives of Cooley reviewed the status of the negotiation of the transaction documents and AbbVie’s due diligence process, noting that while AbbVie remained engaged, AbbVie continued to make additional due diligence requests and indicated that its completion of due diligence remained the primary outstanding item from its perspective. The Board of Directors directed Landos senior management and advisors to continue to respond to AbbVie’s due diligence requests.

From January 9, 2024 to February 1, 2024, both in person at the JP Morgan Healthcare Conference and telephonically shortly thereafter, members of Landos senior management held meetings with representatives of five companies in the biopharmaceutical and healthcare industries, as Landos has done from time to time in the ordinary course of business. The representatives of each of these companies indicated that such companies would not be interested in a potential strategic transaction with Landos until after top-line results from the Phase 2 trial for NX-13 became available. Mr. Oakes updated the Board of Directors regarding these meetings.

During January 2024 to mid-March 2024, AbbVie continued to make supplemental due diligence requests, conduct diligence calls with Landos and its representatives, and engage in confirmatory due diligence of Landos.

On March 14, 2024, representatives of AbbVie called Mr. Oakes to inform him that AbbVie had completed its due diligence and was prepared to enter into the transaction agreements as soon as possible.

On March 17, 2024, the Board of Directors held a meeting with Landos senior management and representatives of Jefferies and Cooley present. Mr. Oakes reviewed the recent discussions with AbbVie. Representatives from Cooley reviewed the fiduciary duties of the directors, including in the context of a potential sale of the company. Representatives from Cooley then reviewed drafts of the Merger Agreement, CVR Agreement and Voting Agreement that reflected the negotiation of the terms of the agreements by Landos and its advisors as directed by the Board of Directors, noting that the total equity value proposed by AbbVie for the transaction would result in a value of $20.42 per share of Landos common stock at closing and $11.14 per share of Landos common stock with respect to the nominal value of the CVR based on the number of outstanding shares at that time on a fully diluted basis, which number of outstanding shares had increased slightly in the ordinary course in the approximately four months following the November 13 Proposal. Following discussion, the Board of Directors directed Landos senior management and the legal and financial advisors to finalize the terms of the transaction agreements for consideration by the Board of Directors.

From March 17, 2024 through March 22, 2024, Paul Weiss and Cooley worked to finalize drafts of the Merger Agreement, Landos disclosure schedules to the Merger Agreement, CVR Agreement and Voting Agreement.

On March 24, 2024, the Board of Directors held a meeting with Landos senior management and representatives of Jefferies and Cooley present. Representatives of Cooley reviewed the fiduciary duties of the directors, including in the context of a potential sale of the company. The Board of Directors also reviewed the Management Projections and approved them for use in Jefferies’ financial analysis. Representatives of Jefferies then reviewed its financial analysis of the Merger Consideration and rendered Jefferies’ oral opinion (which was subsequently confirmed in writing) to the Board of Directors to the effect that, as of the date of such opinion and based on and subject to the various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken as described in its opinion, the Merger Consideration to be received by the holders of shares (other than Parent, Merger Sub and their respective affiliates) pursuant to the Merger Agreement is fair, from a financial point of view, to such holders. For more information about Jefferies’ opinion, see below under the captions “The Merger—Opinion of Landos’ Financial Advisor”. The Board of Directors also considered

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updates to the customary relationship disclosures previously provided by Jefferies regarding its relationships in the past two years with AbbVie and certain stockholders of Landos, Xontogeny, LLC and funds affiliated with Perceptive Advisors LLC, which updates to the customary relationship disclosures Jefferies provided on March 15. Representatives of Cooley reviewed with the Board of Directors the terms of the proposed final Merger Agreement, CVR Agreement and Voting Agreement. For more information concerning the terms of the agreements, see the section titled “Proposal 1: Adoption of the Merger Agreement.” Following discussion among the directors, after careful consideration, and taking into account the factors described in the section titled “The Merger—Recommendation of the Board of Directors and Reasons for the Merger,” the Board of Directors unanimously (a) determined that the Transactions, including the Merger, are advisable and fair to, and in the best interests of, Landos and its stockholders; (b) authorized and approved the execution, delivery, and performance of the Merger Agreement, the CVR Agreement and the Voting Agreement by Landos and approved the Merger; (c) recommended the adoption of the Merger Agreement by Landos’ stockholders and (d) directed that the Merger Agreement be submitted for consideration by Landos’ stockholders at the Special Meeting.

Later that day, Landos and AbbVie and certain of its affiliates executed the Merger Agreement.

On March 25, 2024, Landos and AbbVie issued a joint press release announcing the execution of the Merger Agreement.

Recommendation of the Board of Directors and Reasons for Recommendation of the Merger

Recommendation of the Board of Directors

The Board of Directors has unanimously (a) determined that the Transactions, including the Merger, are advisable and fair to, and in the best interests of, Landos and its stockholders; (b) authorized and approved the execution, delivery, and performance of the Merger Agreement, the CVR Agreement and the Voting Agreement by Landos and approved the Merger; (c) recommended the adoption of the Merger Agreement by Landos’ stockholders and (d) directed that the Merger Agreement be submitted for consideration by Landos’ stockholders at the Special Meeting.

The Board of Directors unanimously recommends, on behalf of Landos, that you vote (i) “FOR” the adoption the Merger Agreement and (ii) “FOR” the approval of the Adjournment Proposal.

Reasons for Recommendation of the Merger

In the course of reaching its determination and recommendation, the Board of Directors consulted with Landos management, its legal counsel, Cooley, and its financial advisor, Jefferies. The Board of Directors considered a number of factors, including the below non-exhaustive list of material reasons (which are not listed in order of relative importance), and has unanimously (a) determined that the Transactions, including the Merger are advisable and fair to, and in the best interests of, Landos and its stockholders; (b) authorized and approved the execution, delivery, and performance of the Merger Agreement and any applicable ancillary agreements by Landos and unanimously approved the Merger; and (c) recommended the adoption of the Merger Agreement by the holders of Landos common stock and directed that the Merger Agreement be submitted for adoption by Landos’ stockholders at the Special Meeting:

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The Board of Directors also considered a number of uncertainties and risks concerning the Merger and other potentially negative reasons in determining whether to approve the Merger Agreement and the Merger, including the following (which are not listed in any relative order of importance):

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The foregoing discussion of reasons for the recommendation to adopt the Merger Agreement and approve the Merger and the transactions contemplated thereby addresses the reasons considered by the Board of Directors in consideration of its recommendation. In view of the wide variety of reasons considered by the Board of Directors in connection with its evaluation of the Merger and the complexity of these matters, the Board of Directors did not find it practicable to, and did not attempt to, quantify or otherwise assign relative weights to the specific reasons considered in reaching its determination and recommendation. Rather, in considering the information and reasons described above, individual members of the Board of Directors each applied his or her own personal business judgment to the process and may have given differing weights to differing factors. The Board of Directors based its unanimous recommendation on the totality of the information available and the factors presented to and considered by it. This explanation of the Board of Directors’ reasons for the Merger and all other information presented in this section is forward-looking in nature and, therefore, should be read in light of the factors discussed under “Forward-Looking Statements.”

Certain Financial Projections

Landos does not, as a matter of course, regularly prepare long-range projections or publicly disclose forecasts or internal projections as to future performance, revenues, earnings or other results of operations due to, among other reasons, the inherent unpredictability of the underlying assumptions and projections. However, in October 2023, in connection with the Board of Directors’ review of potential strategic alternatives, Landos senior management, at the direction of the Board of Directors, prepared preliminary, draft unaudited financial projections for fiscal years 2024 through 2046 based on the best currently available estimates and good faith judgments of senior management at that time (the “October Preliminary Projections”) to assist the Board of Directors’ strategic review and evaluation of Landos’ intrinsic value as a standalone company and to inform Jefferies’ preliminary financial analyses prepared for the Board of Directors. Following that time, the Board of Directors and Landos senior management continued to discuss the various assumptions reflected in the October

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Preliminary Projections. As a result of these discussions, the October Preliminary Projections were revised to reflect certain changes (as so revised, the “Management Projections”), including, among others, (i) the addition of certain unaudited financial projections associated with Landos’ pipeline assets (i.e., the Management Projections included projections with respect to LABP-73 for treatment of atopic dermatitis, asthma and eosinophilic esophagitis, with a probability of success of 3% for such indications, based on review of market and empirical data with respect to the probability of success to FDA approval for drug candidates in such indications), (ii) the addition of unaudited financial projections for fiscal years 2047 through 2049 to account for the addition of Landos’ pipeline assets to the Management Projections and the timing of Landos senior management’s anticipated loss of exclusivity applicable thereto, (iii) a reduction in the probability of success for NX-13 for treatment of ulcerative colitis (UC) from 30% to 25% based on review of certain market and empirical data and scientific literature with respect to the probability of success to FDA approval for drug candidates in the UC indication and (iv) a reduction in the probability of success for NX-13 for treatment of Crohn’s disease from 25% to 15% based on review of certain market and empirical data and scientific literature with respect to the probability of success to FDA approval for drug candidates in the Crohn’s disease indication. The Management Projections were otherwise materially the same as the October Preliminary Projections. Consistent with the view of the Board of Directors and Landos senior management that the Management Projections then reflected the best available estimates and good faith judgments as to the future financial performance of Landos on a risk adjusted basis at that time, the Board of Directors approved the Management Projections on March 24, 2024 and directed Jefferies to use the Management Projections in connection with the rendering of its fairness opinion to the Board of Directors and its related financial analyses.

The October Preliminary Projections and the Management Projections (each, the “Projections”) reflect estimates and assumptions made by Landos senior management with respect to product launch years, peak sales, loss of exclusivity, probability of success, general business, economic, competitive, regulatory and other market and financial conditions and other future events, all of which are difficult to predict and many of which are beyond Landos’ control. In particular, the Projections, while presented with numerical specificity, necessarily were based on numerous variables and assumptions that are inherently uncertain. Because the Projections cover multiple years, by their nature, they become subject to greater uncertainty with each successive year and are unlikely to anticipate each and every circumstance that could have an effect on Landos’ business and its results of operations. The Projections were developed solely using the information available to Landos senior management at the time they were created and reflect assumptions as to certain business decisions that are subject to change. Important factors that may affect actual results or that may result in the Projections not being achieved include the ability to generate revenue for NX-13 and Landos’ pipeline assets, the ability to obtain regulatory approval for NX-13 and Landos’ pipeline assets and the effect of regulatory actions, including the impact on product launch years, the effectiveness of Landos’ commercial execution, the decisions of actual and potential third-party partners, Landos’ ability to partner and the terms of any such partnering transactions, the success of clinical testing and development, manufacturing and supply availability, patent life and other rights or exclusivity, the effect of global economic conditions and increases in regulatory oversight and other risk factors described in Landos’ annual report on Form 10-K for the fiscal year ended December 31, 2023, subsequent quarterly reports on Form 10-Q and current reports on Form 8-K. The Projections also reflect assumptions as to certain business decisions that are subject to change. Modeling and forecasting the future in the biopharmaceutical industry, in particular, is a highly speculative endeavor.

None of Landos, AbbVie or any of their respective affiliates, advisors or other representatives makes any representation to any stockholder regarding the validity, reasonableness, accuracy or completeness of the Projections or the ultimate performance of Landos relative to the Projections. The Projections were not prepared with a view toward public disclosure or toward complying with U.S. generally accepted accounting principles (“GAAP”), the published guidelines of the SEC regarding projections or the guidelines established by the American Institute of Certified Public Accountants for preparation and presentation of prospective financial information. Neither Landos’ independent registered public accounting firm, nor any other independent accountants, has audited, reviewed, compiled or performed any procedures with respect to the Projections or expressed any opinion or any form of assurance related thereto. The inclusion of the Projections in this proxy statement does not constitute an admission or representation of Landos that the Projections or the information

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contained therein is material. Except as required by applicable law, neither Landos nor any of its affiliates intends to, and each of them disclaims any obligation to, update, correct or otherwise revise the Projections if any or all of them have changed or change or otherwise have become, are or become inappropriate (even in the short term). These considerations should be taken into account if evaluating the Projections, which were prepared as of an earlier date.

The Projections should be evaluated, if at all, in conjunction with the historical financial statements and other information regarding Landos in its public filings with the SEC. The Projections were developed by Landos senior management on a standalone basis without giving effect to the Merger or the other transactions contemplated by the Merger Agreement, and therefore the Projections do not give effect to the proposed Merger or any changes to Landos’ operations or strategy that may be implemented after the consummation of the Merger, including any costs incurred in connection with the proposed Merger. Furthermore, the Projections do not take into account the effect of any failure of the proposed Merger to be completed and should not be viewed as accurate or continuing in that context.

The Projections further reflect subjective judgment in many respects and, therefore, are susceptible to multiple interpretations and periodic revisions based on actual experience and business developments. The inclusion of the Projections should not be regarded as an indication that Landos or anyone who received the Projections then considered, or now considers, the Projections to be necessarily predictive of actual future events, and this information should not be relied upon as such. Landos senior management views the Projections as being subject to inherent risks and uncertainties associated with such long-range projections.

The risk-adjusted net revenue, earnings before interest and taxes (“EBIT”) and unlevered free cash flow contained in the Projections set forth below are “non-GAAP financial measures,” which are financial performance measures that are not calculated in accordance with GAAP. Non-GAAP financial measures should not be viewed as a substitute for GAAP financial measures and may be different from non-GAAP financial measures used by other companies. Furthermore, there are limitations inherent in non-GAAP financial measures because they exclude charges and credits that are required to be included in a GAAP presentation. Accordingly, non-GAAP financial measures should be considered together with, and not as an alternative to, financial measures prepared in accordance with GAAP. The most directly comparable GAAP financial measure for risk-adjusted net revenue is revenue, the most directly comparable GAAP financial measure for EBIT is net income (loss) and the most directly comparable GAAP financial measure for unlevered free cash flow is net cash provided by (used in) operating activities. Certain SEC rules that otherwise would require a reconciliation of a non-GAAP financial measure to a GAAP financial measure in other contexts do not apply to non-GAAP financial measures provided to a Board of Directors or financial advisors in connection with a proposed business combination transaction such as the proposed Merger if the disclosure is included in a document such as this proxy statement. In addition, reconciliations of non-GAAP financial measures to a GAAP financial measure were not provided to or relied upon by the Board of Directors or Jefferies in connection with the proposed Merger. Accordingly, Landos has not provided a reconciliation of the financial measures included in the Projections to the relevant GAAP financial measures. The Projections may differ from published analyst estimates and forecasts and do not take into account any events or circumstances after the date they were prepared, including the announcement of the Merger.

In light of the foregoing factors and uncertainties inherent in the Projections, holders of shares are cautioned not to place undue, if any, reliance on the summary of the Projections set forth below. The information and tables set forth below are included solely to give Landos stockholders access to a summary of the Management Projections and, solely for informational purposes, the October Preliminary Projections that were made available to the Board of Directors and Jefferies and are not included in this proxy statement in order to influence any stockholder’s decision to vote with respect to the proposal to adopt the Merger Agreement or for any other purpose:

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Management Projections

(U.S. dollars in millions)

October Preliminary Projections

The October Preliminary Projections were provided to Jefferies and to the Board of Directors in October 2023 to assist the Board of Directors’ strategic review and evaluation of Landos’ intrinsic value as a standalone company as described in the section above captioned “ —Background of the Merger.” Since the October Preliminary Projections were not approved by the Board of Directors, the October Preliminary Projections are included in this proxy statement solely for informational purposes and only to contextualize the events described in the section above captioned “ —Background of Merger” during the relevant period. The Board of Directors did not rely on the October Preliminary Projections in approving the Merger Agreement and the Merger and Jefferies did not rely on the October Preliminary Projections for purposes of its analyses in connection with the delivery of the opinion described in the section below captioned “—Opinion of Landos’ Financial Advisor.”

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(U.S. dollars in millions)

Opinion of Landos’ Financial Advisor

Landos retained Jefferies as its financial advisor in connection with a possible sale, disposition or other business transaction involving Landos. In connection with this engagement, Landos requested that Jefferies evaluate the fairness, from a financial point of view, to holders of shares (other than Parent, Merger Sub and their respective affiliates) of the Merger Consideration to be received by such holders pursuant to the Merger Agreement. At a meeting of the Board of Directors held on March 24, 2024, Jefferies rendered its oral opinion to the Board of Directors, which was subsequently confirmed by delivery of a written opinion dated March 24, 2024, to the effect that, as of the date of such opinion and based on and subject to various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken as described in its opinion, the Merger Consideration to be received by the holders of shares (other than Parent, Merger Sub and their respective affiliates) was fair, from a financial point of view, to such holders.

The full text of Jefferies’ opinion, which describes the various assumptions made, procedures followed, matters considered and limitations and qualifications on the review undertaken by Jefferies, is attached as Annex C to this proxy statement and is incorporated herein by reference. Landos encourages you to read the opinion carefully and in its entirety. Jefferies’ opinion was provided for the use and benefit of the Board of Directors in its consideration of the Merger. Jefferies’ opinion did not address the relative merits of the transactions contemplated by the Merger Agreement as compared to any alternative transaction or opportunity that might be available to Landos, nor did it address the underlying business decision by Landos to engage in the Merger or the terms of the Agreements or the documents referred to therein. Jefferies’ opinion did not constitute a recommendation as to how any holder of shares should vote on the Merger or any matter related thereto. The following summary is qualified in its entirety by reference to the full text of Jefferies’ opinion.

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In arriving at its opinion, Jefferies, among other things:

In Jefferies’ review and analyses and in rendering its opinion, Jefferies assumed and relied upon, but did not assume any responsibility to independently investigate or verify, the accuracy and completeness of all financial and other information that was supplied or otherwise made available to Jefferies by Landos or that was publicly available to Jefferies (including, without limitation, the information described above), or that was otherwise reviewed by Jefferies. Jefferies relied on assurances of the management of Landos that it was not aware of any facts or circumstances that would make any of the foregoing information incomplete, inaccurate or misleading. Jefferies did not obtain any independent evaluation or appraisal of any of the assets or liabilities (contingent, accrued, derivative, off-balance sheet or otherwise) of, nor did Jefferies conduct a physical inspection of any of the properties or facilities of, Landos, and Jefferies was not furnished with and assumed no responsibility to obtain or conduct any such evaluations, appraisals or physical inspections. Jefferies did not evaluate and does not express any opinion as to the solvency or fair value of Landos or any other entity under any laws relating to bankruptcy, insolvency or similar matters. Jefferies’ analyses and opinion also do not consider any actual or potential arbitration, litigation, claims or possible unasserted claims, investigations or other proceedings to which Landos or any other entity is or in the future may be a party or subject.

With respect to the financial forecasts and estimates provided to and, at Landos’ direction, examined by Jefferies, Jefferies noted that projecting future results of any company is inherently subject to uncertainty. However, Jefferies was informed by Landos, and Jefferies assumed, that such financial forecasts and estimates were reasonably prepared on bases reflecting the best currently available estimates and good faith judgments of the management of Landos as to, and are an appropriate basis upon which to evaluate, the future financial performance of Landos and the other matters covered thereby (including management’s forecasts and assessments regarding the probability of achieving the Milestone under the CVR Agreement). Jefferies expressed no opinion as to Landos’ financial forecasts or estimates or the assumptions on which they were made.

Jefferies relied upon the assessments of the management of Landos as to, among other things, (a) the potential impact on Landos of market, competitive and other conditions, trends and developments in and prospects for, and governmental, regulatory and legislative matters relating to or affecting, the biopharmaceutical industry, and the immunology sector thereof, including with respect to the pricing of and third-party coverage and reimbursement for pharmaceutical products, (b) matters relating to the CVR Product (as defined in the CVR Agreement), the potential use and indications for such product, related technology and intellectual property and regulatory approval processes and risks, including with respect to the probability and timing for achieving the Milestone or Landos’ expected use and indications for the CVR Product, the development, clinical testing, manufacturing and commercialization of the CVR Product and related use and indications, the validity and duration of licenses and patents, and (c) Landos’ existing and future agreements and arrangements with, and ability to attract, retain and/or replace, key employees and consultants, customers, suppliers and other commercial and collaboration relationships. Jefferies assumed that there would not be any developments with respect to any such matters that would be material in any respect to Jefferies’ analyses or opinion.

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Jefferies’ opinion was based on economic, monetary, regulatory, market and other conditions existing and which could be evaluated as of the date thereof. Jefferies expressly disclaimed any undertaking or obligation to advise any person of any change in any fact or matter affecting Jefferies’ opinion of which Jefferies becomes aware after the date thereof.

Jefferies made no independent investigation of, and Jefferies expressed no view or opinion as to, any legal, regulatory, accounting or tax matters affecting or relating to Landos or the Merger and Jefferies assumed the correctness in all respects material to its analyses and opinion of all legal, regulatory, accounting and tax advice given to Landos and the Board of Directors, including, without limitation, advice as to the legal, regulatory, accounting and tax consequences of the terms of, and transactions contemplated by, the Agreements. In addition, in preparing its opinion, Jefferies did not take into account any tax consequences of the transaction to any holder of shares. Jefferies assumed that the final form of the Agreements were substantially similar to the last drafts of the Agreements reviewed by Jefferies in all respects material to its analyses and opinion. Jefferies also assumed that the Merger would be consummated in accordance with the terms of the Merger Agreement without waiver, modification or amendment of any term, condition or agreement. Jefferies also assumed that, in the course of obtaining the necessary governmental, regulatory or third party approvals, consents, waivers and releases for the Merger, no delay, limitation, restriction or condition would be imposed or occur that would have an adverse effect on Landos, AbbVie or the contemplated benefits of the Merger or that otherwise would be material in any respect to Jefferies’ analyses or opinion.

Jefferies’ opinion was for the use and benefit of the Board of Directors in its consideration of the Merger, and Jefferies’ opinion did not address the relative merits of the transactions contemplated by the Merger Agreement as compared to any alternative transaction or opportunity that might be available to Landos, nor did it address the underlying business decision by Landos to engage in the Merger or the terms of the Agreements or the documents referred to therein. Jefferies’ opinion did not constitute a recommendation as to how any holder of shares should vote on the Merger or any matter related thereto. In addition, Jefferies’ opinion did not address, the fairness to, or any other consideration of, the holders of any class of securities (including Landos’ pre-funded warrants), creditors or other constituencies of Landos, other than the holders of shares. Jefferies expressed no opinion as to the price at which shares would trade at any time. Furthermore, Jefferies did not express any view or opinion as to the fairness, financial or otherwise, of the amount or nature of any compensation payable or to be received by any of Landos’ officers, directors or employees, or any class of such persons, in connection with the Merger relative to the Merger Consideration to be received by holders of shares. Jefferies’ opinion was authorized by the fairness committee of Jefferies.

In connection with rendering its opinion to the Board of Directors, Jefferies performed certain financial and comparative analyses, including those described below. The following summary is not a complete description of all analyses performed and factors considered by Jefferies in connection with its opinion. The preparation of a financial opinion is a complex process involving subjective judgments and is not necessarily susceptible to partial analysis or summary description. These analyses necessarily involved complex considerations and judgments concerning financing characteristics and other factors that could affect the public trading or other values of the companies concerned.

Jefferies believes that its analyses and the summary below must be considered as a whole and in context and that selecting portions of its analyses and factors, without considering all analyses and factors or the narrative description of the analyses, could create a misleading or incomplete view of the processes underlying Jefferies’ analyses and opinion. Jefferies did not draw, in isolation, conclusions from or with regard to any one factor or method of analysis for purposes of its opinion, but rather arrived at its ultimate opinion based on the results of all analyses undertaken by it and assessed as a whole.

The estimates of the future performance of Landos in or underlying Jefferies’ analyses are not necessarily indicative of future results or values, which may be significantly more or less favorable than those estimates. In performing its analyses, Jefferies considered industry performance, general business and economic conditions

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and other matters, many of which are beyond the control of Landos. Estimates of the financial value of companies or businesses do not purport to be appraisals or necessarily reflect the prices at which companies, businesses or securities actually may be sold or acquired. Accordingly, the estimates used in, and the implied reference ranges resulting from, any particular analysis described below are inherently subject to substantial uncertainty and should not be taken as Jefferies’ view of the actual value of Landos or its businesses or securities.

The terms of the Merger were determined through negotiations between Landos and AbbVie, and the decision by Landos to enter into the Agreements was solely that of the Board of Directors. Jefferies’ opinion and financial analyses were only one of many factors considered by the Board of Directors in its evaluation of the Merger and should not be viewed as determinative of the views of the Board of Directors or Landos’ management with respect to the Merger or the Merger Consideration.

Financial Analyses

The summary of the financial analyses described in this section is a summary of the material financial analyses reviewed with the Board of Directors and performed by Jefferies in connection with its analyses and opinion. Considering the data below without considering the full narrative description of the financial analyses, including the methodologies and assumptions underlying the analyses, could create a misleading or incomplete view of Jefferies’ financial analyses. The order in which the financial analyses summarized below appear does not necessarily reflect the relative importance or weight given to such analyses. The following quantitative information, to the extent that it is based on market data, is based on market data as it existed on or before March 24, 2024, and is not necessarily indicative of current or future market conditions. For purposes of the financial analyses described below, (i) the term “Upfront Merger Consideration” refers to the $20.42 per share cash amount, without interest thereon, payable in the Merger and (ii) the term “Implied Merger Consideration” refers to the Upfront Merger Consideration plus, with respect to the $11.14 per share Milestone Payment, without interest thereon, the implied present value (as of March 31, 2024) of such contingent payment based on the probability and expected timing of achieving the Milestone, per Landos’ management, and calculated using calculated using a discount rate of 15% (which was the midpoint of a selected discount rate range of 14.0% to 16.0%, based on an estimate of Landos’ weighted average cost of capital), which implied present value is equal to $3.80 per Share.

Discounted Cash Flow Analysis

Jefferies performed a discounted cash flow analysis of Landos by calculating the estimated present value of the stand-alone Unlevered Free Cash Flow, as described further in in the section of this proxy titled “ —Certain Financial Projections”, that Landos was forecasted to generate during the calendar years ending December 31, 2024 through December 31, 2049 based on the Management Projections. The present values of the Unlevered Free Cash Flow of Landos were then calculated using a selected discount rate range of 14.0% to 16.0%, based on Jefferies’ estimate of Landos’ weighted average cost of capital, to determine a range of implied enterprise values for Landos. Jefferies then added Landos’ forecasted net cash of $29 million and the present value of Landos’ net operating loss carryforwards, in each case, as of March 31, 2024 and as provided by Landos management, to calculate a range of implied equity values, and divided the result by the number of fully diluted outstanding shares to calculate a range of implied per share equity values for Landos. This analysis indicated a reference range of implied per share equity values of $14.51 to $24.90 per share, as compared to the Upfront Merger Consideration of $20.42 per share and the Implied Merger Consideration of $24.22 per share.

Certain Additional Information

Jefferies observed certain additional information that was not considered part of Jefferies’ financial analysis with respect to its opinion but was noted for informational purposes, including the following:

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Miscellaneous

Landos has agreed to pay Jefferies for its financial advisory services in connection with the Merger an aggregate fee based upon a percentage of the transaction value of the Merger, which fee is estimated as of the date of this proxy statement to be approximately $6.7 million, of which $1.5 million became payable upon delivery of Jefferies’ opinion to the Board, $2.95 million of which is payable contingent upon the closing of the Merger and $2.25 million of which is payable contingent upon payment of the Milestone Payment. In addition, Landos agreed to reimburse Jefferies for certain expenses, including fees and expenses of counsel, incurred in connection with Jefferies’ engagement and to indemnify Jefferies and related parties against liabilities arising out of or in connection with the services rendered and to be rendered by Jefferies under its engagement.

During the two-year period prior to the date of Jefferies’ opinion, Jefferies and its affiliates did not provide financial advisory or financing services to Landos or AbbVie for which Jefferies or its affiliates received fees. Jefferies and its affiliates may provide financial advisory and/or financing services to Landos and AbbVie and/or their respective affiliates in the future, for which services Jefferies and its affiliates would expect to receive compensation. In the ordinary course of its business, Jefferies and its affiliates may trade or hold securities or financial instruments (including loans and other obligations) of Landos and AbbVie and/or their respective affiliates for its own account and for the accounts of its customers and, accordingly, may at any time hold long or short positions in those securities.

Jefferies was selected as Landos’ financial advisor in connection with the Merger because, among other things, Jefferies is an internationally recognized investment banking firm with substantial experience in mergers and acquisition transactions and based on its familiarity with Landos’ business and industry. Jefferies is regularly engaged in the valuation of businesses and their securities in connection with mergers, acquisitions, negotiated underwritings, competitive bids, secondary distributions of listed and unlisted securities and private placements.

Interests of Landos’ Directors and Executive Officers in the Merger

When considering the recommendation of the Board of Directors that you vote to approve the proposal to adopt the Merger Agreement, you should be aware that our directors and executive officers may have interests in the Merger that are different from, or in addition to, the interests of stockholders generally, as more fully described below. The Board of Directors was aware of and considered these interests, among other matters, to the extent that they existed at the time, in reaching the determination that the terms and conditions of the Merger and the Merger Agreement were advisable, fair to and in the best interests of Landos and its stockholders, in reaching its decision to approve and adopt the Merger Agreement and in making their recommendation that the stockholders vote in favor of the adoption of the Merger Agreement. For more information, please see the below subsections of this Section captioned “The Merger—Interests of Landos’ Directors and Executive Officers in the Merger.”

Arrangements with AbbVie

As of the date of this proxy statement, none of our executive officers has entered into any agreement with AbbVie or any of its affiliates regarding employment with, or the right to purchase or participate in the equity of, the Surviving Corporation or one or more of its affiliates. Prior to and following the Closing, however, certain of our executive officers may have discussions, and following the Closing, may enter into agreements with,

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AbbVie, Parent or Merger Sub, their subsidiaries or their respective affiliates regarding employment with, or the right to purchase or participate in the equity of, the Surviving Corporation or one or more of its affiliates.

Insurance and Indemnification of Directors and Executive Officers

Under the Merger Agreement, all rights to indemnification, advancement of expenses, and exculpation by Landos existing (the “Indemnification Obligations”) in favor of those persons who are directors or officers of Landos as of the date of the Merger Agreement or have been directors or officers of Landos in the past (collectively, the “Indemnified Persons”) for their acts and omissions occurring prior to the Effective Time, as provided in the organizational documents of Landos (as in effect as of the date of the Merger Agreement) or in any indemnification agreements between Landos and said Indemnified Persons that was made available to Parent (as in effect as of the date of the Merger Agreement) shall survive the Effective Time and shall not be amended, repealed, or otherwise modified in any manner that would adversely affect the rights thereunder of any Indemnified Person, and shall be observed and maintained by the Surviving Corporation and its subsidiaries to the fullest extent available under applicable law for a period of six (6) years from the Effective Time, and any claim made pursuant to such rights within such six (6)-year period shall continue to be subject to the Merger Agreement’s conditions and the rights provided under the Merger Agreement until disposition of such claim.

Additionally, from the Effective Time until the sixth anniversary of the Closing Date, Parent and the Surviving Corporation (together with their successors and assigns, the “Indemnifying Parties”) shall, to the fullest extent permitted under law and Landos’ organizational documents in effect as of the date of the Merger Agreement, indemnify and hold harmless each Indemnified Person in his or her capacity as an officer or director of Landos against all losses, claims, damages, liabilities, fees, expenses, judgments, or fines incurred by such Indemnified Person due to such Indemnified Person’s capacity as an officer or director of Landos in connection with any pending or threatened legal proceeding based on, arising out of, or relating to, in whole or in part, the fact that such Indemnified Person is or was a director or officer of Landos at or prior to the Effective Time and pertaining to any and all matters pending, existing, or occurring at or prior to the Effective Time, whether asserted or claimed prior to, at or after the Effective Time, including any such matter arising under any claim with respect to the transactions contemplated by the Merger Agreement and the other agreements delivered pursuant thereto, including the Merger.

Without limiting the foregoing, from the Effective Time until the sixth anniversary of the Closing Date, the Indemnifying Parties shall also, to the fullest extent permitted under applicable law, advance reasonable and documented out-of-pocket costs and expenses (including reasonable and documented attorneys’ fees) incurred by the Indemnified Persons in connection with matters for which such Indemnified Persons are eligible to be indemnified pursuant to the Merger Agreement within twenty (20) business days after receipt by Parent of a written request for such advance, subject to the execution by such Indemnified Persons of appropriate undertakings in favor of the Indemnifying Parties to repay such advanced costs and expenses if it is ultimately determined in a final and nonappealable judgment of a court of competent jurisdiction that such Indemnified Person is not entitled to be indemnified under the Merger Agreement or under applicable law or Landos’ organizational documents or indemnification agreement at the time of the Merger Agreement.

Any Indemnified Person wishing to claim indemnification under the Merger Agreement upon learning of any such legal proceeding, shall promptly notify Parent thereof in writing, but the failure to so notify shall not relieve Parent or Landos of any liability it may have to such Indemnified Person except to the extent such failure prejudices the Indemnifying Party. In the event of any legal proceeding: (i), subject to the terms and conditions of the Merger Agreement, Parent or Landos shall have the right to assume the defense thereof; (ii) the Indemnified Persons shall cooperate in the defense of any such matter if Parent or Landos elects to assume such defense, and Parent and Landos shall cooperate in the defense of any such matter if Parent or Landos elects not to assume such defense; (iii) the Indemnified Persons shall not be liable for any settlement effected without their prior written consent if Parent or Landos elects to assume such defense and Parent and Landos shall not be liable for any settlement effected without their prior written consent if Parent or Landos elects not to assume such defense; (iv) Parent and Landos shall not have any obligation hereunder to any Indemnified Person if and when a court of

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competent jurisdiction shall ultimately determine, and such determination shall have become final, that the indemnified action of such Indemnified Person in the manner contemplated hereby is prohibited by applicable law; and (v) all rights to indemnification in respect of any such legal proceedings shall continue until final disposition of all such legal proceedings.

If a “tail policy” is not obtained by Landos prior to the Effective Time, from the Effective Time until the sixth anniversary of the Closing Date, the Surviving Corporation shall, and Parent shall cause the Surviving Corporation to, maintain, in effect, the existing directors’ and officers’ and fiduciary liability insurance policies maintained by Landos as of the date of the Merger Agreement for the benefit of Landos, its subsidiaries and the Indemnified Persons who are currently covered by such existing policies with respect to their acts and omissions occurring prior to the Effective Time in their capacities as directors and officers of Landos (as applicable), on terms with respect to coverage, deductibles and amounts no less favorable than the existing policy; provided that, at or prior to the Effective Time, Landos shall, unless otherwise directed by Parent in writing, through a nationally recognized insurance broker approved by Parent (such approval not to be unreasonably withheld, delayed, or conditioned) purchase a six-year “tail” policy for the existing policies effective as of the Effective Time and if an applicable “tail policy” has been obtained, it shall be deemed to satisfy all obligations to obtain and/or maintain insurance pursuant to the Merger Agreement; provided that in no event shall the Surviving Corporation be required to pay annual premiums (or premium for a “tail policy”) in excess of three hundred percent (300%) of the annual premiums currently payable by Landos with respect to such current policies, it being understood that if the annual premiums payable for such insurance coverage exceeds such amount, Parent shall be obligated to cause Landos to obtain policies with the greatest coverage available for a cost equal to such amount.

Employee Benefits

For more information, please see the section of this proxy statement captioned “Proposal 1: Adoption of the Merger Agreement—Employee Benefits.”

Treatment of Landos Options and Landos RSUs

As of April 10, 2024, there were 3,119,226 shares of common stock outstanding, 476,187 shares of common stock subject to outstanding Landos Options, and 254,238 shares of common stock subject to outstanding Landos RSUs and. The Landos Options held by Landos’ non-employee directors and the Landos Options and Landos RSUs held by Landos’ executive officers immediately before the Effective Time will be treated as described below.

The Merger Agreement provides that, at the Effective Time, subject to all required withholding taxes, each:

(i) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is less than or equal to the Closing Amount will be cancelled and converted into the right to receive (A) an amount in cash, without interest, equal to the product of (1) the excess, if any, of the Closing Amount over the exercise price per share of common stock of such Landos Option, multiplied by (2) the number of shares of common stock then subject to such Landos Option and (B) one (1) CVR per share of common stock subject to such Landos Option;

(ii) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is greater than the Closing Amount will be cancelled without any consideration being payable in respect thereof, and have no further force or effect; and

(iii) Landos RSU that is unvested and outstanding as of immediately prior to the Effective Time, will be cancelled and converted into the right to receive (A) an amount in cash, without interest, in respect thereof equal to the Closing Amount multiplied by the number of shares of common stock subject to such Landos RSU and (B) one (1) CVR.

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For more information, please see the section of this proxy statement captioned “Proposal 1: Adoption of the Merger Agreement—Closing Amount—Treatment of Landos Options and Landos RSUs.”

Payments Upon Termination at or Following Change in Control

Employment Agreement with Gregory Oakes

In connection with his appointment as the Chief Executive Officer of Landos, Mr. Oakes and Landos entered into an employment agreement, effective as of June 20, 2022 (the “Oakes Agreement”). Pursuant to the terms of the Oakes Agreement, Mr. Oakes’ employment is at will and may be terminated at any time by us or Mr. Oakes.

If we terminate Mr. Oakes’ employment without “Cause,” or if Mr. Oakes terminates his employment for “Good Reason” (each, as defined in the Oakes Agreement) at any time except on or within twelve (12) months following the effective date of a Corporate Transaction, as defined in our 2019 Equity Incentive Plan (such period, the “Corporate Transaction Measurement Period”), Mr. Oakes will be eligible to receive (i) severance payments, in the form of salary continuation, in an amount equal to 12 months of his then-current base salary, (ii) payment of COBRA premiums for a period of up to 12 months, (iii) eligibility to receive a bonus for the prior calendar year if no bonus has been paid at the time of termination (the “Completed Year Bonus”); (iv) an additional payment equivalent to the pro rata portion of Mr. Oakes’ current year target bonus, prorated to reflect the partial year of service (the “Pro Rata Bonus”); (v) forgiveness of his obligation to repay the Retention Bonus (as defined in the Oakes Agreement), if applicable; and (vi) accelerated vesting of all outstanding unvested time-based equity awards that would have become vested during the 12 months following the termination date.

If we terminate Mr. Oakes’ employment without Cause or if Mr. Oakes terminates his employment for Good Reason during the Corporate Transaction Measurement Period, Mr. Oakes will be eligible to receive (i) a lump sum severance payment in an amount equal to 18 months of his then-current base salary, (ii) payment of COBRA premiums for a period of up to 18 months, (iii) eligibility for the Completed Year Bonus; (iv) the Pro Rata Bonus; (v) forgiveness of his obligation to repay the Retention Bonus, if applicable; and (vi) 100% accelerated vesting of all outstanding unvested time-based equity awards as of the termination date.

For the purposes of the Oakes Agreement, “Cause” generally means that Landos has determined in its sole discretion that Mr. Oakes has engaged in any of the following: (i) a material breach of any covenant or condition under the Oakes Agreement, the confidential information agreement between Mr. Oakes and Landos, or other similar written agreement between Landos and Mr. Oakes; (ii) any material act constituting dishonesty, fraud, immoral or disreputable conduct that is deemed by the Board of Directors in its reasonable, good faith discretion to be injurious to Landos or its reputation; (iii) any conduct which constitutes a felony under applicable law; (iv) material violation of any Landos policy or any material act of misconduct, in either case that is deemed by the Board of Directors in its reasonable, good faith discretion to be injurious to Landos or its reputation; (v) refusal to follow or implement a written clear and reasonable directive of the Board of Directors; (vi) breach of fiduciary duty; or (vii) gross negligence or gross incompetence in the performance of Mr. Oakes’s duties or failure to substantially perform such duties (other than due to disability or illness) after the expiration of fifteen (15) days without cure after written notice of such failure.

For the purposes of the Oakes Agreement, “Good Reason” generally means the occurrence of any of the following conditions without Mr. Oakes’s consent, after Mr. Oakes’s provision of written notice to Landos of the existence of such condition (which notice must be provided as described in the Oakes Agreement within thirty (30) days of the initial existence of the condition and must specify the particular condition in reasonable detail), provided that Landos has not first provided notice to Mr. Oakes of its intent to terminate Mr. Oakes’s employment: (i) a material reduction in Mr. Oakes’s duties, responsibilities or authorities, including a requirement that Mr. Oakes report to anyone other than the Board, provided, however, that neither the conversion of Landos to a subsidiary, division or unit of an acquiring entity in connection with a Corporate Transaction (as defined in the Plan) nor any change in Mr. Oakes’s reporting relationship as a result of such Corporate

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Transaction will be deemed a “material reduction,” unless Mr. Oakes’s duties, responsibilities or authorities with respect to the business of Landos are materially reduced; (ii) a material (greater than 10%) reduction by Landos of Mr. Oakes’s base salary or Target Percentage (as defined in the Oakes Agreement) (except in the case of either an across-the-board reduction in salaries or Target Percentage of similarly situated employees or a temporary reduction due to financial exigency); (iii) the relocation by Landos of Mr. Oakes’s principal place of employment by fifty (50) or more miles from Mr. Oakes’s then-current principal place of employment, provided that Mr. Oakes agrees to relocate to Landos’ executive office when that office is established, and such relocation shall not be “Good Reason” so long as the executive office is in the Northeastern United States; or (iv) a material breach of the Oakes Agreement. Notwithstanding the foregoing, Good Reason shall only exist if Landos is provided a thirty (30) day period to cure the event or condition giving rise to Good Reason, and it fails to do so within that cure period and, additionally, Mr. Oakes must resign for such Good Reason condition by giving notice as described in the Oakes Agreement within thirty (30) days after the period for curing the violation or condition has ended.

The severance benefits described above are conditioned upon Mr. Oakes executing and making effective and irrevocable a separation agreement that includes a general release as well as his compliance with certain non-competition, non-solicitation, non-disparagement and non-disclosure obligations, resignation from all positions with our company and return of all company property.

Severance Agreement with Dr. Fabio Cataldi

We have entered into a severance agreement with Dr. Cataldi, effective September 5, 2022 (the “Cataldi Severance Agreement”). Pursuant to the Cataldi Severance Agreement, if we terminate Dr. Cataldi’s employment without “Cause” or if Dr. Cataldi terminates his employment for “Good Reason” (each as defined in the Cataldi Severance Agreement) at any time, Dr. Cataldi will be eligible to receive severance payments, in the form of salary continuation, in an amount equal to 12 months of his then-current base salary. In addition, if we terminate Dr. Cataldi’s employment without Cause or if Dr. Cataldi terminates his employment for Good Reason at any time during the 12 months following the effective date of a Corporate Transaction, as defined in our 2019 Equity Incentive Plan, Dr. Cataldi will be eligible to receive 100% accelerated vesting of all outstanding unvested time-based equity awards as of the termination date.

For the purposes of the Cataldi Severance Agreement, “Cause” generally means that Landos has determined in its sole discretion that Dr. Cataldi has engaged in any of the following: (i) a material breach of any covenant or condition under the Cataldi Severance Agreement, the confidential information agreement between Dr. Cataldi and Landos, or other similar written agreement between Landos and Dr. Cataldi; (ii) any material act constituting dishonesty, fraud or immoral or disreputable conduct that is deemed by the Board of Directors in its reasonable, good faith discretion to be injurious to Landos or its reputation; (iii) any conduct which constitutes a felony under applicable law; (iv) material violation of any Landos policy or any material act of misconduct, in either case that is deemed by the Board of Directors in its reasonable, good faith discretion to be injurious to Landos or its reputation; (v) refusal to follow or implement a written clear and reasonable directive of the Board of Directors; (vi) breach of fiduciary duty; or (vii) gross negligence or gross incompetence in the performance of Dr. Cataldi’s duties or failure to substantially perform such duties (other than due to disability or illness) after the expiration of fifteen (15) days without cure after written notice of such failure.

For the purposes of the Cataldi Severance Agreement, “Good Reason” generally means the occurrence of any of the following conditions without Dr. Cataldi’s consent, after Dr. Cataldi’s provision of written notice to Landos of the existence of such condition (which notice must be provided as described in Section 4.1 within thirty (30) days of the initial existence of the condition and must specify the particular condition in reasonable detail), provided that Landos has not first provided notice to Dr. Cataldi of its intent to terminate Dr. Cataldi’s employment: (i) a material reduction in Dr. Cataldi’s duties, responsibilities or authorities, including a requirement that Dr. Cataldi report to anyone other than Landos’ Chief Executive Officer, provided, however, that neither the conversion of Landos to a subsidiary, division or unit of an acquiring entity in connection with a Corporate Transaction nor any change in Dr. Cataldi’s reporting relationship as a result of such Corporate

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Transaction will be deemed a “material reduction,” unless Dr. Cataldi’s duties, responsibilities or authorities with respect to the business of Landos are materially reduced; (ii) a material (greater than 10%) reduction by Landos of Dr. Cataldi’s base salary (as defined in the offer letter between Dr. Cataldi and Landos dated July 26, 2022 (the “Offer Letter”)) or target Annual Bonus (as defined in the Offer Letter) (except in the case of either an across-the-board reduction in salaries and/or annual bonuses of similarly situated employees or a temporary reduction due to financial exigency); (iii) the relocation by Landos of Dr. Cataldi’s principal place of employment by fifty (50) or more miles from Dr. Cataldi’s then-current principal place of employment, provided that Dr. Cataldi agrees to relocate to Landos’ executive office when that office is established, and such relocation shall not be “Good Reason” so long as the executive office is in the Northeastern United States; or (iv) a material breach of the Cataldi Severance Agreement. Notwithstanding the foregoing, Good Reason shall only exist if Landos is provided a thirty (30) day period to cure the event or condition giving rise to Good Reason, and it fails to do so within that cure period and, additionally, Dr. Cataldi must resign for such Good Reason condition by giving notice as described in the Cataldi Severance Agreement within thirty (30) days after the period for curing the violation or condition has ended.

The severance benefits described above are conditioned upon Dr. Cataldi executing and making effective and irrevocable a separation agreement that includes a general release as well as his compliance with certain non-competition, non-solicitation, non-disparagement and non-disclosure obligations, resignation from all positions with our company and return of all company property.

For more information, please see the section of this proxy statement captioned “Quantification of Potential Payments to Certain Landos Executive Officers in Connection with the Merger” below for a quantification of the severance amounts payable to certain of our executive officers on a qualifying termination. The aggregate amount of severance that would be paid to other executive officers, Mr. Oakes and Dr. Cataldi, in connection with a qualifying termination under the Oakes Agreement and the Cataldi Severance Agreement, respectively, is $1,606,714. Patrick Truesdell separated employment prior to the execution of the Merger Agreement and is not eligible to receive severance as a result of the Merger.

Quantification of Potential Payments to Certain Landos Executive Officers in Connection with the Merger

For purpose of the following table, we have assumed that the employment of all executive officers will terminate immediately following the Merger in a manner that entitles them to benefits under the Oakes Agreement and the Cataldi Severance Agreement. The estimated value of the severance payments and benefits, excluding equity acceleration, assuming the closing of the Merger occurs on April 30, 2024, for each of our executive officers is set forth below. For more information, see the section of this proxy statement captioned “The Merger —Interests of Landos’ Directors and Executive Officers” below for a quantification of the amounts that the named executive officers will receive in respect of vested equity awards at the Effective Time.

Severance Compensation

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Equity Awards Held by Landos’ Executive Officers and Non-employee Directors

As discussed above at “Treatment of Landos Options and Landos RSUs”, at the Effective Time, each Landos Option and Landos RSU will be cancelled and automatically converted into the right to receive an amount in cash, without interest, equal to the product of (i) the aggregate number of shares subject to such award, multiplied by (ii) the Closing Amount (or, for each Landos Option, the excess, if any, of the Closing Amount over such Landos Option’s per share exercise price), subject to any required withholding of taxes.

Each of our executive officers is eligible to receive the applicable vesting acceleration benefits with respect to his or her equity awards described above under the heading “Payments Upon Termination at or Following Change in Control.”

Equity Interests of Landos’ Executive Officers and Non-Employee Directors

The following table sets forth the number of shares of common stock and the number of shares of common stock underlying equity awards held by each of Landos’ executive officers and non-employee directors that would be outstanding as of April 30, 2024 (which, solely for purposes of this proxy statement, is the assumed Closing Date of the Merger). The table also sets forth the values of these shares and equity awards, determined as the number of shares multiplied by the Closing Amount (minus the applicable per share exercise price for any Landos Options). Except for the awards described herein, no additional shares of common stock or equity awards were granted to any executive officer or non-employee director in contemplation of the Merger.

Equity Interests of Landos’ Executive Officers and Non-Employee Directors

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Appraisal Rights

If the Merger is consummated, Landos stockholders (including beneficial owners of shares) who do not vote in favor of the adoption of the Merger Agreement, who properly demand an appraisal of their shares, who continuously hold of record or beneficially own their shares through the Effective Time, who otherwise comply with the procedures of Section 262 of the DGCL and who do not withdraw their demands or otherwise lose their rights to appraisal may, subject to the conditions thereof, seek appraisal of their shares in connection with the Merger under Section 262 of the DGCL, which we refer to as “Section 262.” Unless the context requires otherwise, all references in Section 262 and in this summary to a “stockholder” are to the record holder of shares as to which appraisal rights are asserted, all references in Section 262 and in this summary to the words “beneficial owner” mean a person who is the beneficial owner of shares of stock held either in voting trust or by a nominee on behalf of such person, and all references in Section 262 and in this summary to the word “person” mean any individual, corporation, partnership, unincorporated association or other entity.

The following discussion is not a complete statement of the law pertaining to appraisal rights under the DGCL and is qualified in its entirety by the full text of Section 262, a copy of which is accessible, without subscription or cost, at the following publicly available website, which is incorporated herein by reference: https://delcode.delaware.gov/title8/c001/sc09/index.html#262. The following summary does not constitute any legal or other advice and does not constitute a recommendation that Landos stockholders exercise their appraisal rights under Section 262. STOCKHOLDERS SHOULD CAREFULLY REVIEW THE FULL TEXT OF SECTION 262 AS WELL AS THE INFORMATION DISCUSSED BELOW.

Under Section 262, if the Merger is completed, holders of record of shares of Landos common stock or beneficial owners who (1) submit a written demand for appraisal of such stockholder’s shares of Landos common stock to Landos prior to the vote on the adoption of the Merger Agreement; (2) do not vote, in person by attending via live audio webcast or by proxy, in favor of the adoption of the Merger Agreement; (3) continuously hold of record or beneficially own such shares on the date of making the demand for appraisal through the Effective Time; and (4) otherwise comply with the procedures and satisfy certain ownership thresholds set forth in Section 262 may be entitled to have their shares of Landos common stock appraised by the Delaware Court of Chancery and to receive payment in cash, in lieu of the consideration set forth in the Merger Agreement, for the “fair value” of their shares of Landos common stock, exclusive of any element of value arising from the accomplishment or expectation of the Merger, together with (unless the Delaware Court of Chancery in its discretion determines otherwise for good cause shown) interest on the amount determined by the Delaware Court of Chancery to be the fair value from the effective date of the Merger through the date of payment of the judgment (or in certain circumstances described herein, on the difference between the amount determined to be the fair value and the amount paid by the Surviving Corporation in the Merger to each person entitled to appraisal prior to the entry of judgment in the appraisal proceeding) as described further below. However, after

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an appraisal petition has been filed, the Delaware Court of Chancery, at a hearing to determine persons entitled to appraisal rights, will dismiss appraisal proceedings as to all holders of shares of a class or series of stock that, immediately prior to the closing of the merger, were listed on a national securities exchange who are otherwise entitled to appraisal rights unless (A) the total number of shares of the class or series of stock for which appraisal rights have been pursued or perfected exceeds one percent of the outstanding shares of such class or series as measured in accordance with subsection (g) of Section 262; or (B) the value of the merger consideration in respect of such shares exceeds $1,000,000. We refer to these conditions as the “ownership thresholds.” Given that the shares of Landos common stock are listed on Nasdaq (and assuming such shares remain so listed up until closing of the Merger), then the Delaware Court of Chancery will dismiss any appraisal proceedings as to all holders of Landos common stock who are otherwise entitled to appraisal rights unless one of the ownership thresholds is satisfied.

Unless the Delaware Court of Chancery, in its discretion, determines otherwise for good cause shown, interest on the amount determined to be the fair value of the shares subject to appraisal will accrue and compound quarterly from the Effective Time through the date the judgment is paid at five percent over the Federal Reserve discount rate (including any surcharge) as established from time to time during such period (except that, if at any time before the entry of judgment in the proceeding, the Surviving Corporation makes a voluntary cash payment to each person entitled to appraisal, interest will accrue thereafter only upon the sum of (x) the difference, if any, between the amount so paid and the fair value of the shares as determined by the Delaware Court of Chancery; and (y) interest theretofore accrued, unless paid at that time). The Surviving Corporation is under no obligation to make such voluntary cash payment prior to such entry of judgment.

Under Section 262, where a merger agreement is to be submitted for adoption at a meeting of stockholders, the corporation, not less than twenty (20) days prior to the meeting, must notify each of its stockholders of record as of the record date for notice of such meeting that appraisal rights are available and include in the notice a copy of Section 262 or information directing the stockholders to a publicly available electronic resource at which Section 262 may be accessed without subscription or cost. This proxy statement constitutes Landos’ notice to Landos stockholders that appraisal rights are available in connection with the Merger, and the full text of Section 262 is available at the following URL: https://delcode.delaware.gov/title8/c001/sc09/index.html#262. In connection with the Merger, any holder of shares of Landos common stock who wishes to exercise appraisal rights, or who wishes to preserve such holder’s right to do so, should review Section 262 carefully. Failure to strictly comply with the requirements of Section 262 in a timely and proper manner may result in the loss of appraisal rights under the DGCL. A person who loses his, her or its appraisal rights will be entitled to receive the consideration described in the Merger Agreement without interest and less any applicable withholding taxes. Because of the complexity of the procedures for exercising the right to seek appraisal of shares of Landos common stock, Landos believes that if a person is considering exercising such rights, such person should seek the advice of legal counsel.

Stockholders or beneficial owners wishing to exercise the right to seek an appraisal of their shares of Landos common stock must do ALL of the following:

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In addition, after an appraisal petition has been filed, the Delaware Court of Chancery, at a hearing to determine persons entitled to appraisal rights, will dismiss appraisal proceedings as to all persons who asserted appraisal rights with respect to the shares of Landos common stock unless one of the ownership thresholds is met.

Because a proxy that does not contain voting instructions will, unless revoked, be voted in favor of the adoption of the Merger Agreement, each person who votes by proxy and who wishes to exercise appraisal rights must vote against the adoption of the Merger Agreement or abstain.

Filing Written Demand

A person wishing to exercise appraisal rights must deliver to Landos, before the vote on the adoption of the Merger Agreement at the Special Meeting, a written demand for the appraisal of such person’s shares. In addition, that person must not vote or submit a proxy in favor of the adoption of the Merger Agreement. A vote in favor of the adoption of the Merger Agreement, in person at the Special Meeting or by proxy (whether by mail or via the Internet or telephone), will constitute a waiver of your appraisal rights in respect of the shares so voted and will nullify any previously filed written demands for appraisal. A person exercising appraisal rights must hold, beneficially or of record, the shares on the date the written demand for appraisal is made and must continue to hold the shares through the Effective Time. A proxy that is submitted and does not contain voting instructions will, unless revoked, be voted in favor of the adoption of the Merger Agreement, and it will constitute a waiver of the stockholder’s right of appraisal and will nullify any previously delivered written demand for appraisal. Therefore, a stockholder who submits a proxy and who wishes to exercise appraisal rights must submit a proxy containing instructions to vote against the adoption of the Merger Agreement or abstain from voting on the adoption of the Merger Agreement. Neither voting against the adoption of the Merger Agreement nor abstaining from voting or failing to vote on the proposal to adopt the Merger Agreement will, in and of itself, constitute a written demand for appraisal satisfying the requirements of Section 262. The written demand for appraisal must be in addition to and separate from any proxy or vote on the adoption of the Merger Agreement. A proxy or vote against the adoption of the Merger Agreement will not constitute a demand. A person’s failure to make the written demand prior to the taking of the vote on the adoption of the Merger Agreement at the Special Meeting will constitute a waiver of appraisal rights.

In the case of a written demand for appraisal made by a stockholder of record, the demand must reasonably inform Landos of the identity of the stockholder and that the stockholder intends thereby to demand an appraisal of such stockholder’s shares. In the case of a written demand for appraisal made by a beneficial owner, the demand must reasonably identify the record holder of the shares for which the demand is made, be accompanied by documentary evidence of such beneficial owner’s beneficial ownership of such stock and a statement that such documentary evidence is a true and correct copy of what it purports to be, and provide an address at which such beneficial owner consents to receive notices given by the Surviving Corporation and to be set forth on the Verified List (as defined below).

All written demands for appraisal pursuant to Section 262 should be mailed or delivered to:

Landos Biopharma, Inc.

Attention: Corporate Secretary

P.O. Box 11239

Blacksburg, Virginia 24062

At any time within sixty (60) days after the Effective Time, any person who has not commenced an appraisal proceeding or joined that proceeding as a named party may withdraw such person’s demand for appraisal and accept the per share price offered pursuant to the Merger Agreement, without interest and less any applicable withholding taxes, by delivering to Landos, as the Surviving Corporation, a written withdrawal of the demand for appraisal. Notwithstanding the foregoing, no appraisal proceeding in the Delaware Court of

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Chancery will be dismissed as to any person without the approval of the Delaware Court of Chancery, and such approval may be conditioned upon such terms as the Delaware Court of Chancery deems just, including, without limitation, a reservation of jurisdiction (which we refer to as a “Reservation”) for any Application (as defined below); provided, however, that this shall not affect the right of any person who has not commenced an appraisal proceeding or joined that proceeding as a named party to withdraw such person’s demand for appraisal and to accept the Merger consideration within sixty (60) days after the Effective Time. If the Delaware Court of Chancery does not approve the dismissal of an appraisal proceeding with respect to a person, such person will be entitled to receive only the fair value determined in any such appraisal proceeding, which value could be less than, equal to or more than the per share price being offered pursuant to the Merger Agreement.

Notice by the Surviving Corporation

If the Merger is completed, within ten (10) days after the Effective Time, the Surviving Corporation will notify each stockholder (including any beneficial owner) of each constituent corporation who has properly made a written demand for appraisal pursuant to Section 262, and who has not voted in favor of the adoption of the Merger Agreement, that the Merger has become effective and the effective date thereof.

Filing a Petition for Appraisal

Within 120 days after the Effective Time, but not thereafter, the Surviving Corporation or any person who has complied with Section 262 and is otherwise entitled to appraisal rights under Section 262 may commence an appraisal proceeding by filing a petition in the Delaware Court of Chancery, with a copy served on the Surviving Corporation in the case of a petition filed by any person other than the Surviving Corporation, demanding a determination of the fair value of the shares held by all dissenting stockholders entitled to appraisal. The Surviving Corporation is under no obligation, and has no present intention, to file a petition, and stockholders should not assume that the Surviving Corporation will file a petition or initiate any negotiations with respect to the fair value of the shares of Landos common stock. Accordingly, any persons who desire to have their shares appraised should initiate all necessary action to perfect their appraisal rights in respect of their shares of Landos common stock within the time and in the manner prescribed in Section 262. The failure to file such a petition within the period specified in Section 262 could nullify a previous written demand for appraisal.

Within 120 days after the Effective Time, any person who has complied with the requirements for an appraisal of such person’s shares pursuant to Section 262 will be entitled, upon written request, to receive from the Surviving Corporation a statement setting forth the aggregate number of shares not voted in favor of the adoption of the Merger Agreement and with respect to which Landos has received demands for appraisal, and the aggregate number of stockholders or beneficial owners holding or owning such shares (provided that where a beneficial owner makes a demand for appraisal directly, the record holder of such shares shall not be considered a separate stockholder holding such shares for purposes of this aggregate number). Such statement must be given within ten (10) days after receipt by the Surviving Corporation of the written request for such a statement or within ten (10) days after the expiration of the period for delivery of demands for appraisal, whichever is later.

If a petition for an appraisal is duly filed by any person other than the Surviving Corporation, service of a copy thereof must be made upon the Surviving Corporation, which will then be obligated within twenty (20) days after such service to file with the Delaware Register in Chancery a duly verified list (which we refer to as the “Verified List”) containing the names and addresses of all persons who have demanded appraisal for their shares and with whom agreements as to the value of their shares have not been reached. The Delaware Court of Chancery may order that notice of the time and place fixed for the hearing of such petition be given to the Surviving Corporation and all of the persons shown on the Verified List at the addresses stated therein. The costs of any such notice are borne by the Surviving Corporation.

After notice is provided to the applicable persons as required by the Delaware Court of Chancery, at the hearing on such petition, the Delaware Court of Chancery will determine the persons who have complied with

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Section 262 and who have become entitled to appraisal rights thereunder. The Delaware Court of Chancery may require the persons who demanded appraisal for their shares and who hold stock represented by stock certificates to submit their stock certificates to the Register in Chancery for notation thereon of the pendency of the appraisal proceedings. If any person fails to comply with this requirement, the Delaware Court of Chancery may dismiss the proceedings as to such person. Upon application by the Surviving Corporation or by any person entitled to participate in the appraisal proceeding, the Delaware Court of Chancery may, in its discretion, proceed to trial upon the appraisal prior to the final determination of the persons entitled to an appraisal. Any person whose name appears on the Verified List may participate fully in all proceedings until it is finally determined that such person is not entitled to appraisal rights under Section 262.

Given that the shares of Landos common stock are listed on Nasdaq (and assuming such shares remain so listed up until closing of the Merger), the Delaware Court of Chancery will dismiss any appraisal proceedings as to all holders of shares of Landos common stock who are otherwise entitled to appraisal rights unless one of the ownership thresholds is met.

Determination of Fair Value

After the Delaware Court of Chancery determines the persons entitled to appraisal and, with respect to Landos common stock, that at least one of the ownership thresholds above has been satisfied in respect of persons seeking appraisal rights, then the appraisal proceeding will be conducted in accordance with the rules of the Delaware Court of Chancery, including any rules specifically governing appraisal proceedings. Through such proceeding, the Delaware Court of Chancery will determine the “fair value” of the shares of Landos common stock, exclusive of any element of value arising from the accomplishment or expectation of the Merger, together with interest, if any, to be paid upon the amount determined to be the fair value. Unless the Delaware Court of Chancery in its discretion determines otherwise for good cause shown, interest from the effective date of the Merger through the date of payment of the judgment will be compounded quarterly and will accrue at five percent over the Federal Reserve discount rate (including any surcharge) as established from time to time during the period between the effective date of the Merger and the date of payment of the judgment. However, the Surviving Corporation has the right, at any time prior to the Delaware Court of Chancery’s entry of judgment in the proceedings, to make a voluntary cash payment to each person seeking appraisal. If the Surviving Corporation makes a voluntary cash payment pursuant to subsection (h) of Section 262, interest will accrue thereafter only on the sum of (x) the difference, if any, between the amount paid by the Surviving Corporation in such voluntary cash payment and the fair value of the shares as determined by the Delaware Court of Chancery; and (y) interest accrued before such voluntary cash payment, unless paid at that time.

In determining fair value, the Delaware Court of Chancery will take into account all relevant factors. In Weinberger v. UOP, Inc., the Supreme Court of Delaware discussed the factors that could be considered in determining fair value in an appraisal proceeding, stating that “proof of value by any techniques or methods which are generally considered acceptable in the financial community and otherwise admissible in court” should be considered, and that “[f]air price obviously requires consideration of all relevant factors involving the value of a company.” The Delaware Supreme Court stated that, in making this determination of fair value, the court must consider market value, asset value, dividends, earnings prospects, the nature of the enterprise and any other facts that could be ascertained as of the date of the Merger that throw any light on future prospects of the merged corporation. Section 262 provides that fair value is to be “exclusive of any element of value arising from the accomplishment or expectation of the Merger.” In Cede & Co. v. Technicolor, Inc., the Delaware Supreme Court stated that such exclusion is a “narrow exclusion [that] does not encompass known elements of value,” but which rather applies only to the speculative elements of value arising from such accomplishment or expectation. In Weinberger, the Supreme Court of Delaware also stated that “elements of future value, including the nature of the enterprise, which are known or susceptible of proof as of the date of the merger and not the product of speculation, may be considered.”

Persons considering seeking appraisal should be aware that the fair value of their shares as so determined by the Delaware Court of Chancery could be more than, the same as or less than the consideration they would

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receive pursuant to the Merger if they did not seek appraisal of their shares and that an opinion of an investment banking firm as to the fairness from a financial point of view of the consideration payable in a Merger is not an opinion as to, and may not in any manner address, fair value under Section 262. ALTHOUGH LANDOS BELIEVES THAT THE PER SHARE PRICE IS FAIR, NO REPRESENTATION IS MADE AS TO THE OUTCOME OF THE APPRAISAL OF FAIR VALUE AS DETERMINED BY THE DELAWARE COURT OF CHANCERY, AND STOCKHOLDERS SHOULD RECOGNIZE THAT SUCH AN APPRAISAL COULD RESULT IN A DETERMINATION OF A VALUE HIGHER OR LOWER THAN, OR THE SAME AS, THE PER SHARE PRICE. Neither Landos nor Parent anticipates offering more than the per share price to any persons exercising appraisal rights, and each of Landos and Parent reserves the rights to make a voluntary cash payment pursuant to subsection (h) of Section 262 and to assert, in any appraisal proceeding, that for purposes of Section 262, the “fair value” of a share of Landos common stock is less than the per share price. If a petition for appraisal is not timely filed or, with respect to Landos common stock, if neither of the ownership thresholds above has been satisfied in respect of persons seeking appraisal rights, then the right to an appraisal will cease.

The Delaware Court of Chancery will direct the payment of the fair value of the shares, together with interest, if any, by the Surviving Corporation to the persons entitled thereto. Payment will be so made to each such person upon such terms and conditions as the Delaware Court of Chancery may order. The Delaware Court of Chancery’s decree may be enforced as other decrees in such Delaware Court of Chancery may be enforced.

The costs of the appraisal proceedings (which do not include attorneys’ fees or the fees and expenses of experts) may be determined by the Delaware Court of Chancery and taxed upon the parties as the Delaware Court of Chancery deems equitable under the circumstances. Upon application of a person whose name appears on the Verified List who participated in the proceeding and incurred expenses in connection therewith (which we refer to as an “Application”), the Delaware Court of Chancery may also order that all or a portion of such expenses, including, without limitation, reasonable attorney’s fees and the fees and expenses of experts, be charged pro rata against the value of all the shares entitled to an appraisal that were not dismissed pursuant to the terms of Section 262 or subject to an award pursuant to a Reservation. In the absence of such determination or assessment, each party bears its own expenses.

If any person who demands appraisal of his, her or its shares of Landos common stock under Section 262 fails to perfect, or loses or validly withdraws, such person’s right to appraisal, such person’s shares of Landos common stock will be deemed to have been converted at the Effective Time into the right to receive the per share price as provided in the Merger Agreement. A person will fail to perfect, or effectively lose, such person’s right to appraisal if no petition for appraisal is filed within 120 days after the Effective Time, if neither of the ownership thresholds above has been satisfied in respect of those seeking appraisal rights with respect to the shares of Landos common stock, or if the person delivers to the Surviving Corporation a written withdrawal of such person’s demand for appraisal and an acceptance of the per share price as provided in the Merger Agreement in accordance with Section 262.

From and after the Effective Time, no person who has demanded appraisal rights in compliance with Section 262 will be entitled to vote such shares of Landos common stock for any purpose or to receive payment of dividends or other distributions on the stock (except dividends or other distributions payable to stockholders of record at a date which is prior to the effective date of the Merger); provided, however, that if no petition for an appraisal is filed within the time provided in Section 262, if neither of the ownership thresholds above has been satisfied in respect of those seeking appraisal rights with respect to the shares of Landos common stock, or if such person delivers to the Surviving Corporation a written withdrawal of such person’s demand for an appraisal and an acceptance of the Merger, within sixty (60) days after the effective date of the Merger, then the right of such person to an appraisal will cease. Notwithstanding the foregoing, no appraisal proceeding in the Delaware Court of Chancery will be dismissed as to any person without the approval of the Court, and such approval may be conditioned upon such terms as the Court deems just, including, without limitation, a Reservation; provided, however, that the foregoing shall not affect the right of any person who has not commenced an appraisal

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proceeding or joined that proceeding as a named party to withdraw such person’s demand for appraisal and to accept the terms offered upon the Merger within sixty (60) days after the effective date of the Merger.

Failure to comply strictly with all of the procedures set forth in Section 262 may result in the loss of appraisal rights. In that event, you will be entitled to receive the per share price for your dissenting shares in accordance with the Merger Agreement, without interest and less any applicable withholding taxes. Consequently, any person wishing to exercise appraisal rights is encouraged to consult legal counsel before attempting to exercise those rights.

Material U.S. Federal Income Tax Consequences of the Merger

The following discussion is a summary of material U.S. federal income tax consequences of the Merger that may be relevant to U.S. Holders and Non-U.S. Holders (each as defined below) whose shares are converted into the right to receive cash and CVRs pursuant to the Merger. This summary is general in nature and does not purport to be a complete analysis of all potential tax effects. The effects of other U.S. federal tax laws, such as estate and gift tax laws, and any applicable state, local or non-U.S. tax laws are not discussed, nor are the effects of the Medicare contribution tax on net investment income, the alternative minimum tax or the special tax accounting rules in Section 451(b) of the Code. This discussion is based upon the Internal Revenue Code of 1986, as amended (the “Code”), Treasury Regulations promulgated under the Code, court decisions, published rulings and administrative pronouncements of the IRS, and other applicable authorities, all as in effect on the date of this proxy statement and all of which are subject to change or differing interpretations at any time, possibly with retroactive effect. This discussion is limited to stockholders who hold their shares as “capital assets” within the meaning of Section 1221 of the Code (generally, property held for investment purposes).

This discussion is for general information only and does not address all of the tax consequences that may be relevant to stockholders in light of their particular circumstances. For example, this discussion does not address the tax consequences that may be relevant to stockholders who may be subject to special treatment under U.S. federal income tax laws, such as:

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If a partnership (including an entity or arrangement, domestic or non-U.S., treated as a partnership for U.S. federal income tax purposes) is a beneficial owner of shares, then the tax treatment of a partner in such partnership will generally depend upon the status of the partner and the activities of the partner and the partnership. Partnerships holding shares and partners therein should consult their tax advisors regarding the consequences of the Merger.

We have not sought, and do not intend to seek, any ruling from the IRS with respect to the statements made and the conclusions reached in the following summary, and no assurance can be given that the IRS will agree with the views expressed herein, or that a court will not sustain any challenge by the IRS in the event of litigation.

THE FOLLOWING SUMMARY IS FOR GENERAL INFORMATIONAL PURPOSES ONLY AND IS NOT TAX PLANNING. WE URGE YOU TO CONSULT YOUR OWN TAX ADVISOR WITH RESPECT TO THE SPECIFIC TAX CONSEQUENCES TO YOU IN CONNECTION WITH THE MERGER IN LIGHT OF YOUR OWN PARTICULAR CIRCUMSTANCES, INCLUDING FEDERAL ESTATE, GIFT AND OTHER NON-INCOME TAX CONSEQUENCES, AND TAX CONSEQUENCES UNDER STATE, LOCAL OR NON-U.S. TAX LAWS.

For purposes of this discussion, a “U.S. Holder” is a beneficial owner of shares that is for U.S. federal income tax purposes:

For purposes of this discussion, a “Non-U.S. Holder” is a beneficial owner of shares that is not a U.S. Holder nor an entity classified as a partnership for U.S. federal income tax purposes.

U.S. Holders

The exchange of shares for cash and CVRs pursuant to the Merger will be a taxable transaction to U.S. Holders for U.S. federal income tax purposes. The amount of gain or loss a U.S. Holder recognizes, and the

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timing and character of a portion of such gain or loss, depends in part on the U.S. federal income tax treatment of the CVRs, with respect to which there is a significant amount of uncertainty. The installment method of reporting any gain attributable to the receipt of a CVR generally will not be available with respect to the disposition of shares pursuant to the Merger because the shares are traded on an established securities market.

There is no legal authority directly addressing the U.S. federal income tax treatment of the receipt of the CVRs in connection with the Merger. The receipt of the CVRs as part of the Merger consideration might be treated as an “open transaction” or as a “closed transaction” for U.S. federal income tax purposes, each discussed below.

Pursuant to U.S. Treasury regulations addressing contingent payment obligations that are analogous to the CVRs, if the fair market value of the CVRs were determined to be “reasonably ascertainable,” a U.S. Holder should treat the transaction as a “closed transaction” and treat the fair market value of the CVRs as part of the consideration received in the Merger for purposes of determining gain or loss. On the other hand, if the fair market value of the CVRs could not be reasonably ascertained, a U.S. Holder should treat the transaction as an “open transaction” for purposes of determining gain or loss. These Treasury regulations state that only in “rare and extraordinary” cases would the value of contingent payment obligations not be reasonably ascertainable. There is no authority directly addressing whether contingent payment rights with characteristics similar to the rights under a CVR should be treated as “open transactions” or “closed transactions,” and such question is inherently factual in nature. We urge you to consult your own tax advisor with respect to the proper characterization of the receipt of, and payments made with respect to, a CVR. The following sections discuss certain U.S. federal income tax consequences of the Merger, as applicable, if the exchange of shares for cash and CVRs pursuant to the Merger, as applicable, is treated as an open transaction or, alternatively, as a closed transaction for U.S. federal income tax purposes. Under either “open” or “closed” transaction treatment, gain or loss generally will be determined separately for each block of shares (that is, shares acquired at the same cost in a single transaction) exchanged pursuant to the Merger. To the extent required to take a position, each of the AbbVie and Landos intend to act consistently for applicable tax purposes with open transaction treatment.

Treatment as Open Transaction. If the transaction is treated as an “open transaction” for U.S. federal income tax purposes, a U.S. Holder should generally recognize capital gain for U.S. federal income tax purposes on the exchange of shares pursuant to the Merger if and to the extent the amount of cash received in such exchange exceeds such U.S. Holder’s adjusted U.S. federal income tax basis in the shares sold or exchanged. However, a U.S. Holder may not be able to recognize loss for U.S. federal income tax purposes in connection with the Effective Time even if its adjusted U.S. federal income tax basis exceeds the amount of cash received as of the Effective Time, and instead may be required to defer recognition of loss (and the determination of the amount of such loss) until the U.S. Holder’s right to receive further payments under the CVRs terminates (e.g. when the Milestone Payment becomes due, the Milestone Achievement Outside Date lapses without achieving the Milestone, or, possibly, if the U.S. Holder abandons its CVRs), as discussed below.

The fair market value of the CVRs generally would not be treated as additional consideration for the shares at the time the CVRs are received in the Merger, and the U.S. Holder would have no U.S. federal income tax basis in the CVRs. Instead, the U.S. Holder would take payments under the CVRs into account when made or deemed made in accordance with the U.S. Holder’s regular method of accounting for U.S. federal income tax purposes. A portion of such payments may be treated as interest income under Section 483 of the Code (as discussed below under “Imputed Interest”) and the balance, in general, would be treated as additional consideration for the disposition of the shares. The portion of payments on the CVRs not treated as imputed interest under Section 483 of the Code will generally be treated as gain to the extent the sum of such payments (and all previous payments under the CVRs), together with the cash received upon the closing of the Merger, exceeds such U.S. Holder’s adjusted U.S. federal income tax basis in the shares surrendered pursuant to the Merger. Subject to the imputed interest rules discussed below, a U.S. Holder that does not receive cash pursuant to the Merger (including for this purpose any cash received as payments on the CVRs) in an amount at least equal to such U.S. Holder’s adjusted U.S. federal income tax basis in the shares surrendered pursuant to the

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Merger may be able to recognize a capital loss upon termination of the U.S. Holder’s right to receive further payments under the CVR (e.g. if the Milestone is achieved and the Milestone Payment becomes due, or the Milestone Achievement Outside Date lapses without achieving the Milestone), or possibly upon such U.S. Holder’s abandonment of its CVRs. Any such capital gain or loss will be long-term if the shares were held for more than one year prior to such disposition. The deductibility of capital losses is subject to certain limitations.

Treatment as Closed Transaction. If the receipt of the CVRs is treated as part of a closed transaction for U.S. federal income tax purposes, then a U.S. Holder generally would recognize capital gain or loss on an exchange of shares pursuant to the Merger, in an amount equal to the difference, if any, between: (i) the amount of cash received plus the fair market value (determined as of the Effective Time) of any CVRs received; and (ii) the U.S. Holder’s adjusted U.S. federal income tax basis in the shares exchanged. The proper method to determine the fair market value of a CVR is not clear. Gain or loss generally would be calculated separately for each block of shares (that is, shares acquired at the same cost in a single transaction) exchanged pursuant to the Merger. Any capital gain or loss recognized will be long-term capital gain or loss if the Holder’s holding period for such shares exceeds one year. The deductibility of capital losses is subject to limitations.

A U.S. Holder’s initial U.S. federal income tax basis in a CVR received in the Merger would equal the fair market value of such CVR as determined for U.S. federal income tax purposes. The holding period for a CVR would begin on the day following the date of the Effective Time.

There is no authority directly addressing the U.S. federal income tax treatment of receiving payments on the CVRs and, therefore, the amount, timing and character of any gain, income or loss with respect to the CVRs would be uncertain. For example, if a payment is made with respect to a CVR, it could be treated as a payment with respect to a sale or exchange of a capital asset or as giving rise to ordinary income. It is unclear how a U.S. Holder of the CVRs would recover its adjusted tax basis with respect to payments thereon. It is also possible that, were the payment to be treated as being made with respect to the sale of a capital asset, a portion of such payment may constitute imputed interest under Section 483 of the Code (as described below under “Imputed Interest”).

Imputed Interest. A portion of the payments made with respect to a CVR may be treated as imputed interest, which would be ordinary income to the U.S. Holder of a CVR. The portion of any payment made with respect to a CVR treated as imputed interest under Section 483 of the Code will be determined at the time such payment is made and generally should equal the excess of: (i) the amount of the payment in respect of the CVRs; over (ii) the present value of such amount as of the Effective Time, calculated using the applicable federal rate published by the IRS as the discount rate. A U.S. Holder must include in its taxable income interest imputed pursuant to Section 483 of the Code using such Holder’s regular method of accounting for U.S. federal income tax purposes.

Non-U.S. Holders

Any gain realized by a Non-U.S. Holder pursuant to the Merger generally will not be subject to U.S. federal income tax unless:

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Generally, if payments are made to a Non-U.S. Holder with respect to a CVR, such Non-U.S. Holder may be subject to withholding at a rate of 30% (or a lower applicable treaty rate) on the portion of any such payments treated as imputed interest (as discussed above under “U.S. Holders – Treatment as Open Transaction”), or possibly a larger portion of the CVR payment depending on the U.S. federal income tax treatment of the CVRs unless such Non-U.S. Holder establishes its entitlement to exemption from or a reduced rate of withholding under an applicable tax treaty by providing the appropriate documentation (generally, IRS Form W-8BEN or W-8BEN-E or other applicable IRS Form W-8) to the applicable withholding agents. As discussed above, the tax treatment of the CVRs is unclear, and it is possible that AbbVie or the applicable withholding agent may be required to withhold additional amounts on payments with respect to the CVRs.

Information Reporting and Backup Withholding

Information reporting and backup withholding (currently, at a rate of twenty-four percent (24%)) may apply to the proceeds received by a stockholder pursuant to the Merger. Backup withholding generally will not apply to (1) a U.S. Holder that furnishes a correct taxpayer identification number and certifies that such stockholder is not subject to backup withholding on IRS Form W-9 (or a substitute or successor form) or (2) a Non-U.S. Holder that (i) provides a certification of such stockholder’s foreign status on the appropriate series of IRS Form W-8 (or a substitute or successor form) or (ii) otherwise establishes an exemption from backup withholding. Stockholders must generally provide the rights agent with the certification documentation descripted in this paragraph with respect to payments on the CVRs. Backup withholding is not an additional tax. Any amounts withheld under the backup withholding rules may be allowed as a refund or a credit against the stockholder’s U.S. federal income tax liability, provided that the required information is timely furnished to the IRS.

Tax information provided to a U.S. Holder and the IRS on IRS Form 1099-B for the year of the Merger may reflect only the cash amounts paid to the U.S. Holder in the Merger and not the fair market value of the U.S. Holder’s interest in payments made (or to be made) on the CVRs. Accordingly, a U.S. Holder that treats the Merger as a “closed transaction” for U.S. federal income tax purposes may receive an IRS Form 1099-B reporting an amount received that is less than the amount such U.S. Holder will realize in the year of the Merger. In addition, any IRS Form 1099-B a U.S. Holder receives with respect to payments on the CVRs may reflect the entire amount of the CVR payments paid to the U.S. Holder (except imputed interest) and therefore may not take into account the fact that the U.S. Holder already included the value of such payments in such U.S. Holder’s amount realized in the year the Merger. As a result, U.S. Holders reporting under this method should not rely on the amounts reported to them on IRS Forms 1099-B with respect to the Merger. U.S. Holders are urged to consult their tax advisors regarding how to accurately report their income under this method.

Withholding on Foreign Entities

Sections 1471 through 1474 of the Code (“FATCA”), impose a U.S. federal withholding tax of thirty percent (30%) on certain payments made to a “foreign financial institution” (as specially defined under these rules) unless such institution enters into an agreement with the U.S. government to withhold on certain payments and to collect and provide to the U.S. tax authorities substantial information regarding certain U.S. account holders of such institution (which includes certain equity and debt holders of such institution, as well as certain account holders that are foreign entities with U.S. owners) or an exemption applies. FATCA also generally will impose a U.S. federal withholding tax of thirty percent (30%) on certain payments made to a non-financial foreign entity unless such entity provides the withholding agent with either a certification that it does not have any substantial direct or indirect U.S. owners or provides information regarding substantial direct and indirect U.S. owners of the entity. An intergovernmental agreement between the United States and an applicable foreign

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country may modify these requirements. FATCA withholding currently applies to payments of dividends and interest. The Treasury Department has released proposed regulations which, if finalized in their present form, would eliminate the federal withholding tax of thirty percent (30%) applicable to the gross proceeds of a sale or other disposition of our common stock. In its preamble to such proposed regulations, the Treasury Department stated that taxpayers may generally rely on the proposed regulations until final regulations are issued.

AbbVie or another applicable withholding agent will be required to withhold tax at a rate of 30% on the portion of payments on the CVRs reported as imputed interest, or possibly a larger portion of the CVR payment depending on the U.S. federal income tax treatment of the receipt of the CVRs, if a Non-U.S. Holder fails to meet prescribed certification requirements. In general, no such withholding will be required with respect to a person that timely provides certifications that establish an exemption from FATCA withholding on a valid IRS Form W-8.

Stockholders are encouraged to consult with their own tax advisors regarding the possible implications of FATCA on the disposition of Landos common stock pursuant to the Merger.

THE FOREGOING SUMMARY DOES NOT PURPORT TO BE A COMPLETE DISCUSSION OF THE POTENTIAL TAX CONSEQUENCES OF THE MERGER OR THE OWNERSHIP OF CVRS. EACH HOLDER SHOULD CONSULT ITS OWN TAX ADVISOR REGARDING THE U.S. FEDERAL, STATE AND LOCAL AND NON-U.S. INCOME, ESTATE AND OTHER TAX CONSIDERATIONS RELATING TO THE MERGER IN LIGHT OF ITS PARTICULAR CIRCUMSTANCES. NOTHING IN THIS SUMMARY IS INTENDED TO BE, OR SHOULD BE CONSTRUED AS, TAX ADVICE.

Regulatory Approvals Relevant to the Merger

Landos, Parent and AbbVie have agreed to use reasonable best efforts to obtain all regulatory approvals (including actions or nonactions, waivers, consents, clearances, decisions, declarations, approvals and, expirations, or terminations of waiting periods from governmental bodies) necessary to consummate the Merger and the other transactions contemplated by the Merger Agreement, subject to certain limitations as set forth in the Merger Agreement.

Closing Conditions

Under the HSR Act and the rules promulgated thereunder, certain acquisitions may not be completed until information has been furnished to the DOJ and the FTC, and the applicable HSR Act waiting period requirements have been satisfied. If, prior to the Effective Time, AbbVie, in consultation with Landos, reasonably determines that a filing under the HSR Act is required in connection with the Merger and other transactions contemplated by the Merger Agreement, then the expiration or earlier termination of all applicable waiting periods the HSR Act will become a condition to the obligations of Parent and Landos to effect the Closing. If there is voluntary commitment or agreement with the DOJ or FTC not to effect the Closing, then the expiration or earlier termination of all applicable waiting periods under such voluntary commitment or agreement will become a condition to the obligations of Parent and Landos to effect the Closing. As of the date of this proxy statement, Landos understands that AbbVie has determined that no filing under the HSR Act is required, and that no voluntary commitment or agreement with the DOJ or FTC not to effect the Closing is in effect.

If, prior to the Effective Time, the CMA indicates in writing to AbbVie that it has decided to formally investigate the Merger and, accordingly, requests AbbVie to submit a merger notice in the form prescribed under the Enterprise Act 2002, and such indication and merger notice is provided by AbbVie to Landos, then the making, expiration, termination, or obtaining of all authorizations, consents, orders, approvals, filings, proceedings, declarations, and expirations of waiting periods, as the case may be, under the applicable Antitrust Laws of the United Kingdom will become a condition to the obligations of Parent and Landos to effect the Closing. As of the date of this proxy statement, Landos understands that the CMA has not made any such indication in writing.

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If, prior to the Effective Time, the EC indicates in writing to AbbVie that a member state of the European Union or the EC is making, or has made, a referral of the Merger to the EC under Article 22 of the EU Merger Regulation, and such indication is provided by AbbVie to Landos, then the making, expiration, termination, or obtaining of all authorizations, consents, orders, approvals, filings, proceedings, declarations, and expirations of waiting periods, as the case may be, under the applicable Antitrust Laws of the European Union will become a condition to the obligations of Parent and Landos to effect the Closing. As of the date of this proxy statement, Landos understands that the EC has not made any such indication in writing.

Regardless of whether the making, expiration, termination, or obtaining of all authorizations, consents, orders, approvals, filings, proceedings, declarations, and expirations of waiting periods under the HSR Act or the applicable Antitrust Laws of the United Kingdom or the European Union becomes a condition to Closing, at any time before or after consummation of the Merger, the DOJ, the FTC, or other governmental body could take such action under the Antitrust Laws as it deems necessary or desirable in the public interest, including seeking to enjoin the completion of the Merger, seeking divestiture of substantial assets of one or more of the parties, requiring the parties to license or hold separate assets or terminate existing relationships and contractual rights, or requiring the parties to agree to other remedies. At any time before or after the completion of the Merger, any state or foreign jurisdiction could take such action under the Antitrust Laws as it deems necessary or desirable in the public interest. Such action could include seeking to enjoin the completion of the Merger, seeking divestiture of substantial assets of one or more of the parties, requiring the parties to license or hold separate assets or terminate existing relationships and contractual rights, or requiring the parties to agree to other remedies. Private parties may also seek to take legal action under the Antitrust Laws under certain circumstances, including by seeking to intervene in a regulatory process or litigate to enjoin or overturn regulatory approvals, any of which actions could significantly impede or even preclude obtaining required regulatory approvals. Landos cannot be certain that a challenge to the Merger will not be made or that, if a challenge is made, Landos will prevail.

Other Regulatory Approvals

One or more governmental agencies may impose a condition, restriction, qualification, requirement or limitation when it grants any necessary approvals and consents. Third parties may also seek to intervene in the regulatory process or litigate to enjoin or overturn regulatory approvals, any of which actions could significantly impede or even preclude obtaining required regulatory approvals. There is currently no way to predict how long it will take to obtain any required regulatory approvals or whether such approvals will ultimately be obtained and, in such case, there may be a substantial period of time between the approval by stockholders and the completion of the Merger.

We cannot assure you that any relevant regulatory clearances and approvals would be timely obtained, obtained at all or that the granting of these regulatory clearances and approvals will not involve the imposition of additional conditions, restrictions, qualifications, requirements or limitations on the completion of the Merger, including the requirement to (i) negotiating, committing to, and effecting, by consent decree, hold separate order, or otherwise, the sale, lease, license, divestiture, or disposition of any asset, right, product or product line, or business of Landos, AbbVie, or any of their respective affiliates, (ii) terminating any existing relationship, contractual right, or obligation of Landos, AbbVie, or any of their respective affiliates, (iii) terminating any venture or other arrangement, (iv) creating any relationship, contractual right, or obligation of Landos, AbbVie or any of their respective affiliates, (v) effectuating any other change or restructuring of Landos, AbbVie or any of their respective affiliates, (vi) undertaking or agreeing to (or requesting or authorizing Landos or any of its subsidiaries to undertake, effective upon the Closing) any requirement or obligation to provide prior notice to, or obtain prior approval from, any governmental body with respect to any transaction, (vii) otherwise taking or committing to take any action with respect to the businesses, product lines, or assets of Landos, AbbVie or any of their respective affiliates, and (viii) any sale, divestiture, disposition or other remedial measure pursuant to the Merger Agreement. These conditions or changes could result in the conditions to the Merger not being satisfied. There is currently no way to predict how long it will take to obtain any relevant regulatory approvals or whether such approvals would ultimately be obtained and, in such case, there may be a substantial period of time between the approval by stockholders and the completion of the Merger.

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Landos and AbbVie have agreed to use reasonable best efforts to obtain all regulatory approvals required to consummate the Merger and the other transactions contemplated by the Merger Agreement, subject to certain limitations as set forth in the Merger Agreement.

Legal Proceedings

As of the filing of this proxy statement, there were no legal proceedings pending related to the Merger.

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PROPOSAL 1: ADOPTION OF THE MERGER AGREEMENT

The following summary describes the material provisions of the Merger Agreement. The descriptions of the Merger Agreement in this summary and elsewhere in this proxy statement are not complete and are qualified in their entirety by reference to the Merger Agreement, a copy of which is attached to this proxy statement as Annex A and incorporated into this proxy statement by reference. You should carefully read and consider the entire Merger Agreement, which is the legal document that governs the Merger, because this summary may not contain all the information about the Merger Agreement that is important to you. The rights and obligations of the parties are governed by the express terms of the Merger Agreement and not by this summary or any other information contained in this proxy statement.

The representations, warranties, covenants and agreements described below and included in the Merger Agreement (i) were made only for purposes of the Merger Agreement and as of specific dates; (ii) were made solely for the benefit of the parties to the Merger Agreement; and (iii) may be subject to important qualifications, limitations and supplemental information agreed to by Landos, AbbVie, Parent and Merger Sub in connection with negotiating the terms of the Merger Agreement and contained in the confidential disclosure schedules. In addition, the representations and warranties have been included in the Merger Agreement for the purpose of allocating contractual risk between Landos, AbbVie, Parent and Merger Sub rather than to establish matters as facts and may be subject to standards of materiality applicable to such parties that differ from those applicable to investors. Stockholders are not third-party beneficiaries under the Merger Agreement and should not rely on the representations, warranties, covenants and agreements or any descriptions thereof as characterizations of the actual state of facts or condition of Landos, AbbVie, Parent or Merger Sub or any of their respective affiliates or businesses. Moreover, information concerning the subject matter of the representations and warranties may change after the date of the Merger Agreement. In addition, you should not rely on the covenants in the Merger Agreement as actual limitations on the respective businesses of Landos, AbbVie, Parent and Merger Sub, because the parties may take certain actions that are either expressly permitted in the confidential disclosure schedule to the Merger Agreement or as otherwise consented to by the appropriate party, which consent may be given without prior notice to the public. The Merger Agreement is described below, and included as Annex A, only to provide you with information regarding its terms and conditions, and not to provide any other factual information regarding Landos, AbbVie, Parent, Merger Sub or their respective businesses. Accordingly, the representations, warranties, covenants and other agreements in the Merger Agreement should not be read alone, and you should read the information provided elsewhere in this document and in our filings with the SEC regarding Landos and its business.

Effects of the Merger; Certificate of Incorporation; Bylaws; Directors and Officers

The Merger Agreement provides that, on the terms and subject to the conditions of the Merger Agreement and in accordance with the DGCL, at the Effective Time (i) Merger Sub will be merged with and into Landos, (ii) the separate corporate existence of Merger Sub will thereupon cease, and (iii) the corporate existence of Landos under the laws of the State of Delaware will continue as the surviving corporation and a wholly owned subsidiary of Parent. The corporation surviving the Merger is sometimes referred to as the “Surviving Corporation.” The Merger will have the effects set forth in the applicable provisions of the DGCL.

At the Effective Time, the certificate of incorporation of Landos shall be amended and restated to conform to Exhibit C of the Merger Agreement until, subject to the terms of the Merger Agreement, thereafter, amended in accordance with the applicable provisions of the DGCL and such certificate of incorporation. The name of the Surviving Corporation will be Landos Biopharma, Inc.

The parties to the Merger Agreement shall take all necessary action such that the bylaws of Merger Sub as in effect immediately prior to the Effective Time will become the bylaws of the Surviving Corporation (except that all references in such bylaws of Merger Sub to its name, date of incorporation, registered office or registered agent shall instead refer to the name, date of incorporation, registered office and registered agent, respectively, of

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the Surviving Corporation) until, subject to the Merger Agreement thereafter amended in accordance with the applicable provisions of the DGCL, the certificate of incorporation of the Surviving Corporation and such bylaws.

Closing and Effective Time

Closing shall take place (i) remotely by electronic exchange of executed documents, commencing at 10:00 a.m., New York City time, on the date that is two (2) business days after the date on which all of the closing conditions of the Merger (described below under the caption “—Conditions to the Closing of the Merger”) shall have been satisfied or waived (other than those conditions that by their nature are to be satisfied by actions to be taken at the Closing, but subject to the satisfaction or waiver thereof at or prior to the Closing) or (ii) at such other place, time, and date as Landos and Parent may agree in writing. On the date of the Closing (or on such other date as Parent and Landos may agree), Parent, Merger Sub and Landos shall cause a certificate of merger (the “Certificate of Merger”) to be filed with the Secretary of State of the State of Delaware and make all other filings or recordings required by the DGCL in connection with the Merger. The Merger will become effective at such time as the Certificate of Merger is duly filed with the Secretary of State of the State of Delaware or at such later date or time as may be agreed by Landos and Parent and specified in the Certificate of Merger in accordance with the DGCL.

Closing Amount

Common Stock

At the Effective Time, and without any further action on the part of the parties or any of Landos’ stockholders, each share of common stock of Landos, par value $0.01 per share that is outstanding immediately prior to the Effective Time (other than Cancelled Shares and Dissenting Shares) shall be converted automatically into the right to receive the Merger Consideration All shares that have been converted into the right to receive the Merger Consideration as provided in the Merger Agreement shall cease to exist and no longer being outstanding, and any holder of book-entry shares, or certificates with respect thereto that immediately prior to the Effective Time represented such shares, shall cease to have any right with respect to such shares other than the right to receive the Merger Consideration.

Treatment of Landos Options and Landos RSUs

The Merger Agreement provides that, at the Effective Time, subject to all required withholding taxes, each:

(i) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is less than or equal to the Closing Amount will be cancelled and converted into the right to receive (A) an amount in cash, without interest, equal to the product of (1) the excess, if any, of the Closing Amount over the exercise price per share of common stock of such Landos Option, multiplied by (2) the number of shares of common stock then subject to such Landos Option and (B) one (1) CVR per share of common stock subject to such Landos Option;

(ii) Landos Option that is outstanding as of immediately prior to the Effective Time, whether or not then vested, having an exercise price per share of common stock that is greater than the Closing Amount will be cancelled without any consideration being payable in respect thereof, and have no further force or effect; and

(iii) Landos RSU that is unvested and outstanding as of immediately prior to the Effective Time will be cancelled and converted into the right to receive (A) an amount in cash, without interest, in respect thereof equal to the Closing Amount multiplied by the number of shares of common stock subject to such Landos RSU and (B) one (1) CVR.

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Treatment of Landos Warrants

At the Effective Time each Landos Warrant shall be deemed to have been exercised in full in a “cashless exercise” pursuant to Sections 9(c) and 10 of the Landos Warrants effective immediately prior to and contingent upon the Closing, and at the Effective Time shall be converted automatically into the right to receive (a) an amount in cash equal to the Closing Amount multiplied by (x) the total number of shares of common stock underlying such Landos Warrant as of immediately prior to the Effective Time multiplied by (y)(A) an amount equal to (1) the Applicable Closing Price minus (2) the applicable exercise price per share of common stock of such Landos Warrant, divided by (B) the Applicable Closing Price and (b) a number of CVRs equal to the total number of shares of common stock underlying such Landos Warrant as of immediately prior to the Effective Time.

The “Applicable Closing Price” is equal to the Closing Sale Price (as defined in the Landos Warrants) per share of common stock as of the Trading Day (as defined in the Landos Warrants) on the date immediately preceding the Closing Date.

Exchange and Payment Procedures

The Merger Agreement provides that the Paying Agent will act as agent for the holders of common stock and will receive the funds to which holders of common stock will become entitled in connection with the Merger. The Paying Agent will act as agent to the stockholders to receive the Closing Amount payments. No later than the Effective Time, Parent will deposit, or will cause to be deposited, in trust for the benefit of holders of the shares, cash in U.S. dollars sufficient to pay the aggregate Closing Amount in exchange for all of the shares outstanding immediately prior to the Effective Time (other than Cancelled Shares), payable upon due surrender of the certificates that, immediately prior to the Effective Time, represented shares (“Certificates”) (or effective affidavits of loss in lieu thereof) or uncertificated shares represented by book-entry (“Book-Entry Shares”) pursuant to the provisions of the Merger Agreement (such cash being referred to as the “Exchange Fund”).

As soon as reasonably practicable after the Effective Time and in any event not later than the third (3rd) business day following the Closing Date, Parent will cause the Paying Agent to mail to each holder of record of shares whose shares were Certificated and converted into the right to receive Merger Consideration pursuant to the Merger Agreement, (i) a letter of transmittal and (ii) instructions for use in effecting the surrender of Certificates in exchange for Merger Consideration. Upon (a) surrender of Certificates to the Paying Agent, together with such letter of transmittal, duly completed, and validly executed in accordance with the instructions thereto, and such other documents as may customarily be required by the Paying Agent in the case of shares that are Certificated or (b) receipt of an “agent’s message” by the Paying Agent in the case of a book-entry transfer of Book-Entry Shares, the holder of such Certificates (or effective affidavits of loss in lieu thereof) or Book-Entry Shares will be entitled to receive in exchange therefor (x) an amount in cash equal to the product of (1) the number of shares represented by such holder’s properly surrendered Certificates (or effective affidavits of loss in lieu thereof) or Book-Entry Shares and (2) the Closing Amount; and (y) a number of CVRs equal to the number of shares represented by such holder’s properly surrendered Certificates (or effective affidavits of loss in lieu thereof) or Book-Entry Shares. Notwithstanding anything to the contrary in the Merger Agreement, no holder of Book-Entry Shares will be required to provide a Certificate or an executed letter of transmittal to the Paying Agent in order to receive the payment that such holder is entitled to receive pursuant to the Merger Agreement. No interest will be paid or accrued on any amount payable upon due surrender of Certificates (or effective affidavits of loss in lieu thereof). In the event of a transfer of ownership of shares that is not registered in the stock transfer books of Landos, payment of Merger Consideration upon due surrender of a Certificate may be paid to such a transferee if the Certificate formerly representing such shares is presented to the Paying Agent, accompanied by all documents required to evidence and effect such transfer and to evidence that any applicable stock transfer taxes have been paid or are not applicable.

Any portion of the Exchange Fund that remains undistributed to the former holders of shares on the twelve (12)-month anniversary of the Effective Time will thereafter be delivered to the Surviving Corporation upon

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demand, and any former holder of shares who has not surrendered their shares in accordance with the Merger Agreement may thereafter look only to the Surviving Corporation for payment of their claim for the Merger Consideration, without any interest thereon, upon due surrender of their shares.

Representations and Warranties

The Merger Agreement contains representations and warranties of Landos, AbbVie, Parent and Merger Sub.

Some of the representations and warranties in the Merger Agreement made by Landos are qualified as to “materiality” or “Material Adverse Effect.” For purposes of the Merger Agreement, a “Material Adverse Effect” means an event, effect, change, occurrence, condition, or development (an “Effect”) that, individually or taken together, has had or would reasonably be expected to have a material adverse effect on the business, assets, properties, liabilities, operations, condition (financial or otherwise), or results of operations of Landos and its subsidiaries, taken as a whole. However, subject to certain exceptions, no Effect arising out of or resulting from any of the following will be deemed either alone or in combination to constitute or will be taken into account when determining whether a Material Adverse Effect has occurred or would reasonably be expected to occur:

It being understood that the exceptions in clauses (a) and (f) will not prevent, or otherwise affect a determination that the underlying cause of any such change, decline or failure referred to therein (if not otherwise falling within any of the exceptions provided by clauses (b) through (e) or (g) and (h) hereof) has been or would be reasonably expected to be a Material Adverse Effect; or except, in the case of each of clauses (c), (d), (e) and (h), to the extent that such Effect adversely disproportionately affects Landos and its subsidiaries, taken as a whole, compared to other similar biopharmaceutical companies, in which case only the incremental disproportionate adverse impact may be taken into account in determining whether there has been, or would reasonably expected to be, a Material Adverse Effect.

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In the Merger Agreement, Landos has made customary representations and warranties to AbbVie, Parent and Merger Sub that are subject, in some cases, to specified exceptions and qualifications contained in the Merger Agreement and the Landos disclosure schedule. These representations and warranties relate to, among other things:

In the Merger Agreement, AbbVie, Parent and Merger Sub have made customary representations and warranties to Landos that are subject, in some cases, to specified exceptions and qualifications contained in the Merger Agreement. These representations and warranties relate to, among other things:

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The representations and warranties contained in the Merger Agreement will not survive the consummation of the Merger.

Conduct of Business Pending the Merger

The Merger Agreement provides that during the Pre-Closing Period, except (i) as expressly required or contemplated under the Merger Agreement or as required by applicable laws or (ii) with the written consent of Parent, which consent may not be unreasonably withheld, conditioned, or delayed, Landos will, and will cause its subsidiaries, use commercially reasonable efforts, to conduct its business in the ordinary course of business as was being conducted prior to the date of the Merger Agreement and preserve intact its material assets, business organization and relations with employees, material customers, suppliers, licensors, licensees, governmental bodies and any other person with whom Landos has material business relationships;.

Without limiting the generality of the foregoing, the Merger Agreement provides that, except (i) as expressly required or contemplated under the Merger Agreement or as required by applicable laws, (ii) with the written consent of Parent, which consent may not be unreasonably withheld, conditioned, or delayed, or (iii) as disclosed in the Landos disclosure schedules to the Merger Agreement, neither Landos nor any subsidiary may:

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Nothing in the Merger Agreement gives to AbbVie, Parent or Merger Sub, directly or indirectly, any right to control or direct the operations of Landos prior to the Effective Time. Prior to the Effective Time, Landos will continue to exercise, consistent with the terms and conditions hereof, complete control and supervision of its operations and those of its subsidiaries.

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The “No Shop” Period—No Solicitation of Other Offers

For purposes of this proxy statement

“Landos Alternative Transaction” means any proposal or offer from any person (or “group,” within the meaning of Section 13(d) of the Exchange Act, of persons) other than AbbVie and its subsidiaries (such person, a “Landos Third Party”), relating to, in a single transaction or series of related transactions, any:

“Superior Proposal” means any bona fide written proposal made by a Landos Third Party to enter into an Landos Alternative Transaction that (i) did not result from a breach of the ‘No Solicitation’ and ‘Change in Recommendation’ provisions in Section 5.3 of the Merger Agreement and (ii) the Board of Directors determines, in its good faith judgment, after consultation with outside financial advisor(s) and outside legal counsel, (a) is reasonably likely to be consummated in accordance with its terms and conditions and is not subject to a diligence or financing condition and (b) is on terms that, if consummated, would result in a transaction more favorable to the stockholders of Landos from a financial point of view than the Transactions, in each case taking into account all financial, regulatory, legal and other aspects of such proposal, and the person making the proposal; provided that, for purposes of this definition of “Superior Proposal,” the references to “20%” in the definition of Landos Alternative Transaction will be deemed to be references to “50%.”

In addition, Landos has agreed not to, and to cause its subsidiaries not to, directly or indirectly, through any of its or their representatives or otherwise, and will not permit or authorize any such person to:

If, at any time prior to obtaining the Required Company Stockholder Vote, Landos receives an inquiry, proposal or offer, the consummation of which would constitute a Landos Alternative Transaction, that did not

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result, directly or indirectly, from Landos’ breach of the Merger Agreement or the AbbVie NDA, but subject to entering into a confidentiality agreement with such person containing terms that are not less favorable to Landos than those contained in the AbbVie NDA, Landos and its representatives may (x) engage in or participate in discussions or negotiations with such person regarding such inquiry, offer or proposal and (y) provide copies of, access to or disclosure of information, properties, facilities, books or records of Landos or its subsidiaries, if and only if, in the case of both clauses (x) and (y), the Board of Directors first determines (i) in good faith, after consultation with its outside financial advisor(s) and outside legal counsel, that such proposal constitutes or would reasonably be expected to constitute or lead to a Superior Proposal and (ii) that the failure to take such actions would be inconsistent with its fiduciary duties under applicable law; and Landos has been, and continues to be, in compliance with its obligations under the Merger Agreement.

Relatedly, if Landos, its subsidiaries or any of their respective affiliates or representatives receives or otherwise become aware of any written or oral inquiry, proposal, request for information or offer that constitutes, contemplates or may reasonably be expected to constitute or lead to a Landos Alternative Transaction, or any request for copies of, or disclosure of, confidential information in relation to a possible Landos Alternative Transaction, Landos will promptly notify Parent and Parent’s counsel, at first orally, and then within twenty-four (24) hours, in writing, of such inquiry, proposal, offer or request, a description of the material terms and conditions and the identity of all persons making any oral inquiry, proposal, offer or request, keep Parent promptly and reasonably informed of the status, the terms of any discussions or negotiations and any developments and discussions relating to any potential Landos Alternative Transaction and promptly provide to Parent a copy of any written proposal or offer, or, if applicable, the proposed definitive agreement and all ancillary documentation, with respect to such Landos Alternative Transaction.

As described below under the caption “—Effect of Termination; Termination Fees,” if prior to the Required Company Stockholder Vote, Landos terminates the Merger Agreement for the purpose of entering into an agreement in respect of a Superior Proposal, concurrently with such termination, Landos must pay the Landos Termination Fee to Parent.

The Board of Directors’ Recommendation; Change in Recommendation

As described above, and subject to the provisions described below, the Board of Directors has made the recommendation that the holders of Landos common stock vote “FOR” the proposal to adopt the Merger Agreement. The Merger Agreement provides that the Board of Directors will not effect a Change in Recommendation except as described below.

Subject to the exceptions described below, during the Pre-Closing Period, the Board of Directors will not take, or fail to take (if applicable), any of the following actions (any such action, an “Change in Recommendation”):

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If Landos receives a Superior Proposal prior to obtaining the Required Company Stockholder Vote, the Board of Directors may make a Change in Recommendation or terminate the Merger Agreement to immediately thereafter enter into a definitive agreement with respect to such Superior Proposal in compliance with the terms of the Merger Agreement, if and only if:

Other than in connection with a Landos Alternative Transaction, the Board of Directors may make a Change in Recommendation in response to any positive material event or development or material change in circumstances with respect to Landos that (i) was not known to the Board of Directors as of or prior to the date of the Merger Agreement (or if known, the material consequences of which were not known or reasonably foreseeable by the Board of Directors) and (ii) does not relate to (x) any change in the market price or trading volume of Landos’ stock, (y) any Landos Alternative Transaction, or (z) Landos meeting or exceeding any internal or analyst’s expectation, forecast, estimate, or prediction in respect of revenues, earnings, or other financial or operating metrics for any period (each, a “Change in Circumstance”), if and only if:

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If the Board of Directors determines that any alternative proposal would cease to be a Superior Proposal by virtue of the revisions proposed by Parent, Landos will promptly (and in any event within twenty-four (24) hours of such determination) so advise Parent, and the parties will amend the Merger Agreement to reflect such offer made by Parent and will take and cause to be taken all such actions as are necessary to give effect to the foregoing.

Each successive (i) amendment to any proposal that results in an increase in, or modification of, the consideration (or value of such consideration) to be received by Landos’ stockholders or other material terms or conditions thereof or (ii) change in material facts and circumstances relating to the Change in Circumstance shall constitute a new proposal or Change in Circumstance (as applicable) and Landos will deliver a new Superior Proposal Notice for the new Superior Proposal; provided that Parent will be afforded only a two (2) business day Matching Period or Change in Circumstances Matching Period (as applicable) from (A) in the case of a Superior Proposal, the later of the date on which Parent received the Superior Proposal Notice for the new Superior Proposal and the date on which Parent received all of the materials with respect to such new Superior Proposal and (B) in the case of a Change in Circumstance, the date on which Parent received the Determination Notice for the new Change in Circumstance.

If Landos provides a Superior Proposal Notice or Determination Notice to Parent on a date that is less than ten (10) business days before the Special Meeting, Landos will either proceed with or will postpone the Special Meeting, as directed by Parent acting reasonably, to a date determined by Parent that is not more than ten (10) business days after the scheduled date of the Special Meeting but in any event Special Meeting will not be postponed to a date which would prevent the Effective Time from occurring on or prior to the End Date.

Employee Benefits

In the Merger Agreement AbbVie acknowledges that a “change in control,” “sale event” or term or concept of similar import within the meaning of the Employee Plans (as defined in the Merger Agreement) will occur at or prior to the Effective Time, as applicable. For a period of one (1) year following the Effective Time, AbbVie will provide, or cause to be provided, to each natural person who is employed by Landos or any of its subsidiaries (or who provides services to Landos or any of its subsidiaries pursuant to an arrangement with a professional employer organization) as of immediately prior to the Effective Time (including any such employee who is on disability or other approved leave) and who continues to be employed by the Surviving Corporation (or any of its affiliates) (or to provide services to the Surviving Corporation (or any of its affiliates) pursuant to an arrangement with a professional employer organization) during such one-year period (each, a “Continuing Employee”) (i) a base salary (or base wages, as the case may be) and target cash incentive compensation opportunities (excluding retention, change in control, and equity-based compensation), in each case, no less favorable than the base salary (or base wages, as the case may be) and target cash incentive compensation

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opportunities (excluding retention, change in control, and equity-based compensation) provided to such Continuing Employee immediately prior to the Effective Time, and (ii) other compensation or benefits (excluding equity-based compensation, severance benefits, retiree welfare benefits, defined benefit pension plans, and change in control plans, programs, perquisites, and arrangements) that are substantially similar in the aggregate to such other compensation or benefits (excluding equity-based compensation, severance benefits, retiree welfare benefits, defined benefit pension plans, and change in control plans, programs, perquisites, and arrangements) provided to such Continuing Employee immediately prior to the Effective Time. AbbVie will provide each Continuing Employee with service credit for purposes of eligibility to participate and vesting and, with respect to severance and vacation benefits only, level of benefits, under AbbVie’s and the Surviving Corporation’s employee benefit plans and arrangements to the extent such Continuing Employee is eligible to participate in such plans and arrangements and coverage under such plans and arrangements replaces coverage under a comparable Employee Plan in which such Continuing Employee participates immediately prior to the Closing Date, with respect to his or her length of service with Landos (and its predecessors) prior to the Closing Date, provided that such service credit would not result in the duplication of benefits under any employee benefit plan or arrangement.

To the extent that service is relevant for eligibility, vesting, or allowances under any health or welfare benefit plan of AbbVie and/or the Surviving Corporation, then AbbVie will use its commercially reasonable efforts to (A) waive all limitations as to pre-existing conditions, exclusions, and waiting periods with respect to participation and coverage requirements applicable to each Continuing Employee, to the extent that such conditions, exclusions, and waiting periods would not apply under a similar employee benefit plan in which such employee participated prior to the Effective Time and (B) ensure that such health or welfare benefit plan will, for purposes of eligibility, vesting, deductibles, co-payments, out-of-pocket maximums, and allowances, credit each Continuing Employee for service and amounts paid prior to the Effective Time with Landos (and its predecessors) to the same extent that such service and amounts paid was recognized prior to the Effective Time under the corresponding health or welfare benefit plan of Landos.

Landos and each of its subsidiaries will adopt resolutions and take all such corporate action as is necessary to terminate each 401(k) plan maintained, sponsored or contributed to by Landos or any of its subsidiaries (collectively, the “Landos 401(k) Plans”), in each case, effective as of the day immediately prior to the Closing Date, and Landos will provide AbbVie with evidence that such Landos 401(k) Plans have been properly terminated, the form of such termination documents will be subject to AbbVie’s review. Landos employees will be eligible to participate in a 401(k) plan maintained by AbbVie or any of its Subsidiaries as soon as reasonably practicable following the Closing Date, and will be entitled to effect a direct rollover of any eligible rollover distributions (as defined in Section 402(c)(4) of the Code) to such 401(k) plan maintained by AbbVie or its subsidiaries.

The Employee Benefits provisions of the Merger Agreement described above are solely for the benefit of the parties to the Merger Agreement, and no such provision is intended to, or will, constitute the establishment or adoption of or an amendment to any employee benefit plan for purposes of ERISA or otherwise, and no current or former employee or other individual associated therewith shall be regarded for any purpose as a third-party beneficiary of the Merger Agreement or have the right to enforce the provisions hereof. Nothing in the Merger Agreement will confer upon any Landos associate any right to continue in the employ or service of AbbVie, the Surviving Corporation, or any subsidiary or affiliate thereof, or shall interfere with or restrict in any way any right that AbbVie, the Surviving Corporation, or any subsidiary or affiliate thereof may have to discharge or terminate the services of any Landos associate at any time for any reason whatsoever, with or without cause.

Efforts to Close the Merger

Under the Merger Agreement, Landos, AbbVie, Parent and Merger Sub will, and will cause their respective affiliates to, use their respective reasonable best efforts to take, or cause to be taken, all actions, to file, or cause to be filed, all documents, and to do, or cause to be done, and to assist and cooperate with the other parties in

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doing, all things necessary, proper, or advisable under applicable Antitrust Laws or Foreign Direct Investment Laws to consummate and make effective the Transactions as soon as reasonably practicable, including:

Without limiting the generality of the foregoing Landos, AbbVie, Parent and Merger Sub will each use its reasonable best efforts to:

Each of Landos, AbbVie, and Merger Sub, will supply as promptly as practicable following written request therefor such information, documentation, other material, or testimony that may be requested by any governmental body, including by using reasonable best efforts to respond promptly to any reasonable written request for additional information, documents or other materials, including any “second request” under the HSR Act, received by any party or any of their respective subsidiaries from any governmental body in connection with such applications or filings for the Transactions. Any of Landos, AbbVie, Parent and Merger Sub may, as it deems advisable and necessary, reasonably designate any competitively sensitive material provided to the other parties as “outside counsel only.” Such materials and the information contained therein will be given only to the

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outside legal counsel of the recipient and will not be disclosed by such outside legal counsel to employees, officers, or directors of the recipient, unless express written permission is obtained in advance from the source of the materials. Each of Landos, AbbVie, Parent and Merger Sub will use reasonable best efforts to share information protected from disclosure under the attorney-client privilege, work product doctrine, joint defense privilege, or any other privilege pursuant to the Merger Agreement so as to preserve any applicable privilege. Neither AbbVie, nor Parent, nor Merger Sub, on one hand, or Landos, on the other, will pull and refile under any applicable Antitrust Laws or Foreign Direct Investment Laws, without the prior written consent of the other. All filing fees under the HSR Act or for any filing required under other Antitrust Laws or Foreign Direct Investment Laws (if any) will be paid by AbbVie.

Under the Merger Agreement, each of Landos, AbbVie, Parent and Merger Sub will (and will cause their respective affiliates, if applicable, to) (i) as promptly as reasonably practicable, make all filings, notifications or other consents as may be required to be made or obtained by the relevant party under Antitrust Laws or Foreign Direct Investment Laws in those jurisdictions identified in the Landos disclosure schedule, (iii) cooperate with each other in determining whether, and promptly preparing and making, any other filing or notification or other consent required to be made with, or obtained from, any other governmental body in connection with the Transactions, and (iv) cooperate with each other and use their respective reasonable best efforts to contest and resist any legal proceeding that is in effect and that prohibits, prevents or restricts consummation of the Transactions.

AbbVie, after prior consultation in good faith with Landos, will have the principal and sole responsibility for devising and implementing the strategy for obtaining any necessary clearances under the Antitrust Laws and Foreign Direct Investment Laws and will control and take the lead in all meetings and communications with any governmental body in connection therewith. In furtherance of the foregoing, Landos will use its reasonable best efforts to consult in advance with AbbVie, obtain AbbVie’s prior written consent (such consent may be withheld, conditioned or delayed in AbbVie’s sole discretion) and to address all of AbbVie’s views and comments prior to taking any substantive position with respect to (i) the filings under the HSR Act or required by any other governmental body under any applicable Antitrust Laws or Foreign Direct Investment Laws and (ii) any written submission or, to the extent practicable, any discussion with any governmental body in connection with obtaining any necessary clearance under the HSR Act or any other Antitrust Law or any Foreign Direct Investment Law.

Notwithstanding anything to the contrary in the Merger Agreement in no event will AbbVie, Parent, Merger Sub or any of their respective affiliates or subsidiaries be obligated to undertake or commit or agree to undertake any of the following actions: (i) negotiating, committing to, and effecting, by consent decree, hold separate order, or otherwise, the sale, lease, license, divestiture, or disposition of any asset, right, product or product line, or business of Landos, AbbVie, or any of their respective affiliates, (ii) terminating any existing relationship, contractual right, or obligation of Landos, AbbVie, or any of their respective affiliates, (iii) terminating any venture or other arrangement, (iv) creating any relationship, contractual right, or obligation of Landos, AbbVie, or any of their respective affiliates, (v) effectuating any other change or restructuring of Landos, AbbVie, or any of their respective affiliates, (vi) undertaking or agreeing to any requirement or obligation to provide prior notice to, or obtain prior approval from, any governmental body with respect to any transaction, (vii) otherwise taking or committing to take any action with respect to the businesses, product lines, or assets of Landos, AbbVie, or any of their respective affiliates, and (viii)  any sale, divestiture, disposition or other remedial measure pursuant to the applicable sections of the Merger Agreement.

Other Covenants

Stockholders Meeting

Subject to the provisions the Merger Agreement and as promptly as practicable after this Proxy Statement is cleared by the SEC, or the date that is ten (10) calendar days after filing the Proxy Statement in preliminary form if, prior to such date, the SEC does not provide comments or indicates that it does not plan to provide comments,

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Landos will (i) take all action required by the DGCL and Landos’ certificate of incorporation and bylaws to duly call, give notice of, convene, and hold the Special Meeting for the purpose of obtaining (A) the Required Company Stockholder Vote and (B) if so desired and mutually agreed, a vote upon other matters of the type customarily brought before a meeting of stockholders in connection with the approval of a merger agreement or the transactions contemplated by such agreement, it being understood that the Special Meeting may also be Landos’ annual meeting of stockholders, with the record date and meeting date of the Special Meeting to be selected after reasonable consultation with Parent, and (ii) use reasonable best efforts to solicit from its stockholders proxies in favor of the approval of the adoption of the Merger Agreement. Additionally, (x) Landos may adjourn, recess, or postpone, and at the request of Parent it will adjourn, recess, or postpone, the Special Meeting for a reasonable period to solicit additional proxies, if Landos or Parent, respectively, reasonably believes there will be insufficient shares represented (either in person or by proxy) to constitute a quorum necessary to obtain the Required Company Stockholder Vote (provided that, unless agreed in writing by Landos and Parent, all such adjournments, recesses or postponements will be for periods of no more than ten (10) business days each) and (y) Landos may adjourn, recess, or postpone the Special Meeting if (I) Landos is required to do so by applicable law or order or request from the SEC or its staff, (II) subject to the Merger Agreement, Landos has notified Parent the Board of Directors intends to make a Change in Recommendation and the applicable notice period thereunder will not have expired prior to the then-scheduled date and time of the Special Meeting or (III) the Board of Directors has determined in good faith (after consultation with outside legal counsel) that such adjournment, recess or postponement is necessary to ensure Landos stockholders have sufficient time to evaluate any information or disclosure that Landos has sent or otherwise made available (including by issuing a press release, filing materials with the SEC or otherwise) to Landos stockholders in advance of the Special Meeting.

Stockholder Litigation

During the Pre-Closing Period, Landos has agreed to, as promptly as possible after obtaining knowledge thereof, notify Parent of any legal proceeding brought by security holders of Landos against Landos or its directors arising out of or relating to the Transactions and provide accurate and complete copies of all pleadings and correspondence relating to such legal proceedings. Landos will control any such legal proceeding brought by security holders of Landos against Landos or its directors arising out of or relating to the Transactions; provided that Landos will give Parent the opportunity to (i) participate in and consult with Landos with respect to any such legal proceeding and (ii) consult on any settlement, release, waiver or compromise of any such legal proceeding, and Landos will in good faith take any comments into account. Landos has also agreed not to enter into any such settlement without Parent’s prior written consent (such consent not to be unreasonably withheld, conditioned, or delayed), except to the extent the settlement is fully covered by Landos’ insurance policies (other than any applicable deductible), but only if such settlement would not result in the imposition of any restriction on the business or operations of Landos.

Conditions to the Closing of the Merger

The obligations of Landos, AbbVie, Parent and Merger Sub, as applicable, to consummate the Merger are subject to the satisfaction or waiver, at or prior to the Effective Time, of customary conditions, including the following:

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Additionally, the obligations of AbbVie, Parent and Merger Sub, as applicable, to consummate the Merger are subject to the satisfaction or waiver of customary conditions, including, the following:

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Lastly, the obligations of Landos to consummate the Merger are subject to the satisfaction or waiver of customary conditions, including, the following:

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Termination of the Merger Agreement

The Merger Agreement may be terminated and the Merger and other transactions contemplated hereby may be abandoned at any time prior to the Effective Time, whether before or after the Required Company Stockholder Vote is obtained:

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In the event of any termination of the Merger Agreement pursuant to the termination rights discussed immediately above (i) the terminating party will give prompt written notice thereof to the other parties, specifying the provision of the Merger Agreement pursuant to which such termination is made, (ii) the Merger Agreement will be of no further force or effect and the Transactions will be abandoned, each as of the date of termination, and (iii) there will be no liability on the part of any party to the Merger Agreement following any such termination except (a) certain sections of the Merger Agreement will survive the termination of the Merger Agreement and will remain in full force and effect, (b) the AbbVie NDA will survive the termination of the Merger Agreement and will remain in full force and effect, in each case, in accordance with its terms, and (iii) notwithstanding any provision of the Merger Agreement, the termination of the Merge Agreement will not relieve any party from any liability for fraud or willful breach of any of its representations, warranties, covenants or agreements set forth in the Merger Agreement.

Effect of Termination; Termination Fees

The Merger Agreement contains certain remedies in the event of a termination. If Parent terminates the Merger Agreement due to a Change in Recommendation, or after Landos’ failure to obtain the Required Company Stockholder Vote after a Change in Recommendation, Landos has agreed to pay to AbbVie the Landos Termination Fee. If Landos terminates the Merger Agreement due to Landos accepting a Superior Proposal, Landos has also agreed, in connection with and as a condition to such termination, to pay AbbVie the Landos Termination Fee.

The Merger Agreement further provides that Landos will pay to AbbVie the Landos Termination Fee if (i) either of Parent or Landos, as applicable, terminates the Merger Agreement (A) on or after the End Date (if the Effective Time has not occurred prior to such date), (B) due to the Required Company Stockholder Vote having not been obtained at the Special Meeting, or (C) due to a breach by Landos of the Merger Agreement such that certain conditions would not be satisfied, and (ii) at or prior to the Special Meeting (in the case of a termination due to the Required Company Stockholder Vote having not been obtained at the Special Meeting) or at or prior to the time of such termination (in the case of a termination due to the Effective Time having not occurred prior to the End Date or due to a breach by Landos of the Merger Agreement such that certain conditions would not be satisfied), any person has publicly made or announced (and has not subsequently withdrawn), or any person has publicly announced an intention (whether or not conditional) to make (and has not subsequently withdrawn), a Landos Alternative Transaction, and (iii) within twelve (12) months after the date of the termination of the Merger Agreement, Landos or any of its subsidiaries enters into a definitive agreement with respect to a Landos Alternative Transaction or consummates a Landos Alternative Transaction.

Specific Performance

Each of AbbVie, Parent, Merger Sub and Landos is entitled to an injunction or injunctions, specific performance, or other non-monetary equitable relief to prevent breaches of the Merger Agreement and to enforce specifically the terms and provisions thereof in the Court of Chancery of the State of Delaware and any state appellate court therefrom or, if such court lacks subject matter jurisdiction, any other state or federal court in the State of Delaware, without proof of damages or otherwise, in addition to any other remedy to which they are entitled under the Merger Agreement.

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Fees and Expenses

Except in certain circumstances specified in the Merger Agreement, all fees and expenses incurred in connection with the Merger Agreement and the Transactions will be paid by the party incurring such expenses, whether or not the Transactions are consummated.

Amendment

Subject to compliance with applicable law, prior to the Effective Time, the Merger Agreement may be amended or supplemented with the approval of each of the Board of Directors and AbbVie; except that after receipt of the Required Company Stockholder Vote, if any such amendment or waiver would require further approval of Landos’ stockholders, the effectiveness of such amendment or waiver will be subject to the approval of Landos’ stockholders.

Governing Law

The Merger Agreement is governed by Delaware law.

Form of Contingent Value Rights Agreement

The Merger Agreement requires that, at or immediately prior to the Effective Time, AbbVie, Parent and the rights agent will enter into the CVR Agreement, substantially in the form attached as Exhibit D to the Merger Agreement (and attached to this proxy statement as Annex B), subject to such changes thereto as permitted under the Merger Agreement. The CVR Agreement will govern the terms of the CVRs.

While no guarantee can be given that any proceeds will be received, each CVR represents a non-tradeable contractual contingent right to receive $11.14, without interest and subject to applicable tax withholdings, upon the achievement of the Milestone prior to the Milestone Achievement Outside Date. There can be no assurance that the Milestone will be achieved prior to the Milestone Achievement Date or that Parent or AbbVie will be required to make the Milestone Payment to holders of CVRs.

The CVRs are contractual rights only and are not transferable except under limited circumstances, specified in the CVR Agreement. The CVRs will not be evidenced by a certificate or other instrument and will not be registered with the SEC or listed for trading. The CVRs will not have any voting or dividend rights and will not represent any equity or ownership interest in Parent, any constituent corporation party to the Merger Agreement or any of their respective affiliates or subsidiaries. No interest will accrue on any amounts payable on the CVRs.

Except for the rights of the rights agent set forth in the CVR Agreement, only holders of not less than 50% of the outstanding CVRs as set forth in the register kept by the rights agent will have the sole right, on behalf of all holders of CVRs, by virtue of or under any provision of the CVR Agreement, to institute any action or proceeding with respect to the CVR Agreement, and no individual holder of CVRs or other group of holders will be entitled to exercise such rights. However, the CVR Agreement will not limit the ability of an individual CVR holder to seek the Milestone Payment upon the achievement of the Milestone solely to the extent such payment amount has been finally determined in accordance with the terms of the CVR Agreement and has not been paid within the period contemplated by the CVR Agreement. Additionally, the only rights and interests of the CVR holders (or any person seeking the benefit of any CVR) in respect of a CVR will be those set forth in the CVR Agreement and no CVR holder (or any person acting on their behalf or for their benefit) may enforce any other right or interest against any person in respect of a CVR.

The CVR Agreement will be terminated, and no payments will be required to be made, upon the earliest to occur of (a) the payment by the rights agent to each holder of CVRs of the Milestone Payments (if any) required to be paid under the terms of the CVR Agreement and (b) the failure to achieve the Milestone on or before the

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Milestone Achievement Outside Date. For the avoidance of doubt, the right of any CVR holder to receive the Milestone Payment with respect to the Milestone, and any covenants and obligations of Parent (other than in relation to any undistributed Milestone Payments in accordance with the terms of the CVR Agreement), will be terminated and of no force or effect if the Milestone is not achieved before the Milestone Achievement Outside Date.

Voting Agreement

Concurrently with the entry into and in connection with the Merger Agreement, on March 24, 2024, Parent and Landos entered into the Voting Agreement with Xontogeny, LLC and Perceptive Advisors LLC and certain of their affiliates, pursuant to which such stockholders have agreed to vote their aggregate shares in favor of the adoption of the Merger Agreement and approval of the Merger at the Special Meeting. As of March 22, 2024, Xontogeny, LLC and Perceptive Advisors LLC and certain of their affiliates beneficially owned an aggregate of approximately 57.6% of the outstanding shares of Landos common stock. The Voting Agreement will terminate upon termination of the Merger Agreement and certain other specified events.

The Board of Directors unanimously recommends, on behalf of Landos, that you vote “FOR” this proposal.

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PROPOSAL 2: THE ADJOURNMENT PROPOSAL

We are asking you to approve a proposal to adjourn the Special Meeting to a later date or dates if the Board of Directors determines that it is necessary or appropriate, including to solicit additional proxies if there are insufficient votes to adopt the Merger Agreement at the time of the Special Meeting. If the Board of Directors determines that it is necessary or appropriate, we will ask our stockholders to vote only on this Adjournment Proposal and not to vote on the proposal to adopt the Merger Agreement.

In the Adjournment Proposal, we are asking our stockholders to approve a proposal to authorize the Board of Directors, in its discretion, to adjourn the Special Meeting to a later date or dates, if necessary or appropriate, including to solicit additional proxies to approve the proposal to adopt the Merger Agreement if there are insufficient votes to adopt the Merger Agreement at the Special Meeting. If stockholders approve the Adjournment Proposal, we could adjourn the Special Meeting and any adjourned session of the Special Meeting and use the additional time to solicit additional proxies, including soliciting proxies from stockholders that have previously returned properly executed proxies voting against adoption of the Merger Agreement. Among other things, approval of the Adjournment Proposal could mean that, even if we had received proxies representing a sufficient number of votes against adoption of the Merger Agreement such that the proposal to adopt the Merger Agreement would be defeated, we could adjourn the Special Meeting without a vote on the adoption of the Merger Agreement and seek to convince the holders of those shares to change their votes to votes in favor of adoption of the Merger Agreement. Additionally, we may seek to adjourn the Special Meeting if a quorum is not present or otherwise at the discretion of the chairman of the Special Meeting.

Vote Required and Board of Directors Recommendation

Approval of the Adjournment Proposal requires either (i) if a quorum is present, the affirmative vote of the majority of the shares present in person, by remote communication, if applicable, or represented by proxy duly authorized at the Special Meeting and entitled to vote generally on the subject matter or (ii) if a quorum is not present, the vote of the holders of a majority of the shares represented at the Special Meeting. Assuming the Special Meeting is held solely by means of remote communication, as it is currently scheduled to be, no shares will be present in person at the Special Meeting, and only shares present virtually or represented by proxy at the Special Meeting will be able to be voted.

For the purpose of the Adjournment Proposal, (i) a failure to vote virtually or by proxy at the Special Meeting (including failure to give instruction to brokers, banks or other nominees on any of the proposals to be voted on at the Special Meeting for shares held in “street name”) will have no effect on the outcome of the Adjournment Proposal (but such shares will not be counted for purposes of determining whether a quorum is present at the Special Meeting, which may make it harder to establish a quorum for the transaction of business at the Special Meeting), and (ii) abstentions will have the same effect as a vote “AGAINST” the Adjournment Proposal, whether or not a quorum is present. If your shares are deemed present or represented by proxy at the Special Meeting, then a failure to vote your shares will have no effect on the outcome of the Adjournment Proposal if a quorum is present but will have the same effect as a vote “AGAINST” the Adjournment Proposal if a quorum is not present. Shares of Landos common stock represented by properly executed, timely received and unrevoked proxies will be voted in accordance with the instructions indicated thereon. If a stockholder returns a properly signed and dated proxy card without indicating voting preferences on such proxy card, the shares of Landos common stock represented by that proxy will be counted as present for purposes of determining the presence of a quorum for the Special Meeting and all of such shares will be voted as recommended by the Board of Directors.

We do not expect any “broker non-votes” on the Adjournment Proposal, but if there are any, they will be counted for the purpose of determining whether a quorum is present. If there are “broker non-votes,” each broker non-vote will have no effect on the Adjournment Proposal.

The Board of Directors unanimously recommends, on behalf of Landos, that you vote “FOR” approval of this proposal.

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MARKET PRICES AND DIVIDEND DATA

Our common stock is listed on Nasdaq under the symbol “LABP.” As of    , 2024 there were      shares of common stock outstanding held by approximately      stockholders of record. The actual number of stockholders is greater than this number of record holders and includes stockholders who are beneficial owners, but whose shares are held in street name by brokers and other nominees. We have never declared or paid any cash dividends on our common stock.

On    , 2024 the latest practicable trading day before the printing of this proxy statement, the closing price for our common stock on Nasdaq was $   per share. You are encouraged to obtain current market quotations for our common stock.

Following the Merger, there will be no further market for our common stock and it will be delisted from Nasdaq and deregistered under the Exchange Act. As a result, following the Merger we will no longer file periodic reports with the SEC. In the event that the Merger is not consummated, our payment of any future dividends would be at the discretion of our Board of Directors and will depend on then-existing conditions, including our financial condition, operating results, contractual restrictions, capital requirements, business prospects, and other factors our Board of Directors may deem relevant.

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth the beneficial ownership of our capital stock as of March 31, 2024 by: